Assessment of bone quality using finite element analysis based upon micro-CT images.
Assessment of bone quality using finite element analysis based upon micro-CT images.
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DOI：
10.4055/cios.2009.1.1.40
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发表时间：
2009-03
影响因子：
2.5
通讯作者：
Kim YE
中科院分区：
文献类型：
--
作者：
Rhee Y;Hur JH;Won YY;Lim SK;Beak MH;Cui WQ;Kim KG;Kim YE
评价基于显微图像的有限元模型用于确定序贯治疗对大鼠骨质疏松模型骨质量的有效性的可行性。以骨丢失、恢复和维持的概念建立大鼠骨质疏松症模型和治疗性骨质疏松症模型。本研究中使用了30只Sprague-Dawley大鼠。在出生后20周时进行假手术或卵巢切除术，随后进行如下相应的连续试验：（1）仅假手术组，（2）仅卵巢切除组，（3）卵巢切除后维持甲状旁腺激素组，（4）卵巢切除后给予PTH治疗5周后停药组，（5）用PTH治疗5周，然后用17 β-雌二醇治疗的卵巢切除大鼠，和（6）用甲状旁腺激素治疗5周，然后用唑来膦酸治疗的卵巢切除大鼠。使用来自显微计算机断层扫描的显微图像确定组织形态计量学指数。进行有限元分析，以确定椎体的机械性能（刚度和杨氏模量）。使用ANOVA和Bonferroni多组比较程序比较各组之间的性质差异。组3和组6的组织形态计量学和力学性能明显优于组1和组2（p < 0.05）。刚度（σs）和杨氏模量（E）在组（3）中最高，其次是组（6）。基于显微图像的有限元分析提供了一个有用的工具，反映了骨丢失，恢复和维持概念的大鼠椎体的微观结构和力学性能的变化。
To evaluate the feasibility of a micro-image based finite element model to determine the efficacy of sequential treatments on the bone quality in a rat osteoporosis model. Rat osteoporosis and treated osteoporosis models were established with the bone loss, restore and maintain concept. Thirty Sprague-Dawley rats were used in this study. A sham operation or ovariectomy was performed at 20 weeks after birth, which was followed by the respective sequential trials as follows: (1) sham-operation only, (2) ovariectomy only, (3) ovariectomized rats with parathyroid hormone maintenance, (4) ovariectomized rats treated with PTH for 5 weeks and then withdrawal, (5) ovariectomized rats treated with PTH for 5 weeks and then with 17 beta-estradiol, and (6) ovariectomized rats treated with parathyroid hormone for 5 weeks and then treated with zoledronate. The histomorphometry indices were determined using the micro-images from a micro-computed tomogram. Finite element analysis was carried out to determine the mechanical properties (Stiffness and Young's modulus) of the vertebra bodies. The differences in properties between the groups were compared using ANOVA and a Bonferroni's multiple group comparison procedure. The histomorphometry and mechanical properties were significantly better in groups (3) and (6) than in the groups (1) and (2) (p < 0.05). The stiffness (σs) and Young's modulus (E) was highest in group (3) following by group (6). Finite element analysis based on micro-images provides a useful tool that reflects the changes in micro-structural and mechanical properties of a rat vertebral body with the bone loss, restore and maintain concept.