The changing concepts of amyloid.
The changing concepts of amyloid.
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DOI：
10.1043/0003-9985(2001)125
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发表时间：
2009-10
影响因子：
4.6
通讯作者：
Maria M. Picken
中科院分区：
文献类型：
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作者：
Maria M. Picken
75年前出版的第一期《病理学与实验室医学档案》包含了理查德·贾菲的一篇文章，内容是关于实验性诱导小鼠淀粉样变性。这篇论文是一系列里程碑之一，标志着我们对淀粉样变性的持续和不断发展的概念，始于一个多世纪前Virchow的第一次描述。从那时起，通过新开发的技术，如生化分析、电子显微镜和分子遗传学，对淀粉样变的科学理解得到了扩展。作为这些研究的结果，现在已经知道淀粉样变包括整个家族的散发性、家族性和/或遗传性、退行性和感染性疾病过程，通过蛋白质异常折叠和沉积这一共同主题联系在一起。这篇文章试图提供我们对这些疾病的知识现状的概要，包括当前的术语、分类、主要临床症状和诊断。
The first issue of the Archives of Pathology & Laboratory Medicine, published 75 years ago, contained an article by Richard Jaffé on the experimental induction of amyloidosis in mice. This publication was one of a series of milestones that have marked our ongoing and evolving concept of amyloidosis, beginning with the first description by Virchow more than a century ago. Since that time, scientific understanding of amyloidogenesis has expanded through the involvement of newly developed techniques, such as biochemical analysis, electron microscopy, and molecular genetics. As a result of these investigations, it is now known that amyloidoses comprise an entire family of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition. This article seeks to provide a synopsis of the present state of our knowledge with regard to these disorders, including current terminology, classification, major clinical syndromes, and diagnosis.