Transient spine expansion and learning-induced plasticity in layer 1 primary motor cortex
Transient spine expansion and learning-induced plasticity in layer 1 primary motor cortex
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DOI：
10.1523/jneurosci.0584-08.2008
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发表时间：
2008-05-28
影响因子：
5.3
通讯作者：
Dunaevsky, Anna
中科院分区：
文献类型：
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作者：
Harms, Kimberly J.;Rioult-Pedotti, Mengia S.;Dunaevsky, Anna
初级运动皮层第1层水平连接中突触强度的经验依赖性调节可能在运动学习中发挥重要作用。树突棘是大脑中兴奋性突触的主要部位，已知其会响应于各种实验刺激而改变形状。我们使用大鼠运动学习模型，通过切片中的场记录和标记的脊柱的共聚焦成像来检查连接强度，以探索仅由学习简单运动任务引起的变化。我们报告说，运动学习增加反应的大小，而暂时闭塞的长时程增强（LTP）和增加脊柱宽度在第1层。这表明在同一动物中，学习诱导的行为、突触反应和结构变化，表明运动皮层中的LTP样过程介导了技能任务的初始学习。
Experience-dependent regulation of synaptic strength in the horizontal connections in layer 1 of the primary motor cortex is likely to play an important role in motor learning. Dendritic spines, the primary sites of excitatory synapses in the brain, are known to change shape in response to various experimental stimuli. We used a rat motor learning model to examine connection strength via field recordings in slices and confocal imaging of labeled spines to explore changes induced solely by learning a simple motor task. We report that motor learning increases response size, while transiently occluding long-term potentiation (LTP) and increasing spine width in layer 1. This demonstrates learning-induced changes in behavior, synaptic responses, and structure in the same animal, suggesting that an LTP-like process in the motor cortex mediates the initial learning of a skilled task.