Serum uric acid and cognitive function in community-dwelling older adults
Serum uric acid and cognitive function in community-dwelling older adults
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DOI：
10.1037/0894-4105.21.1.136
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发表时间：
2007-01-01
期刊：
影响因子：
2.4
通讯作者：
Pearlson, Godfrey D.
中科院分区：
文献类型：
--
作者：
Schretlen, David J.;Inscore, Anjeli B.;Pearlson, Godfrey D.
在与年龄相关的认知能力下降的可能标志物中，尿酸（UA）是有争议的，因为它具有抗氧化特性，但在通常导致认知障碍的疾病中会增加。在这项对96名老年人的研究中，血清UA轻度升高（但正常）的参与者在处理速度，言语记忆和工作记忆方面得分最低的四分位数的可能性是2.7至5.9倍。即使在控制了年龄、性别、种族、教育、糖尿病、高血压、吸烟和酗酒等因素后，言语记忆和工作记忆差的多变量调整几率仍然显著（ps
Among possible markers of age-related cognitive decline, uric acid (UA) is controversial because it has antioxidant properties but is increased in diseases that often lead to cognitive impairment. In this study of 96 elderly adults, participants with mildly elevated (but normal) serum UA were 2.7 to 5.9 times more likely to score in the lowest quartile of the sample on measures of processing speed, verbal memory, and working memory. Even after controlling for age, sex, race, education, diabetes, hypertension, smoking, and alcohol abuse, the multivariate-adjusted odds of poor verbal memory and working memory remained significant (ps