Interaction between macrocyclic nickel complexes and the nucleotides GMP, AMP and ApG
Interaction between macrocyclic nickel complexes and the nucleotides GMP, AMP and ApG
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DOI：
10.1016/s0162-0134(02)00572-x
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发表时间：
2003-01-15
影响因子：
3.9
通讯作者：
Sletten, E
中科院分区：
文献类型：
--
作者：
Liu, YZ;Sletten, E
Reactions between the nucleotides GMP, AMP and ApG and the complexes Ni(tren), Ni(cyclam) and NiCR in aqueous solution have been monitored by H-1, N-15 NMR and UV spectroscopy. The three nickel complexes display different properties in reactions with nucleotides. Ni(tren) which has a pseudo-octahedral coordination geometry was shown to bind to all three nucleotides. Ni(cyclam) and NiCR, both with four nitrogen atoms in a square planar arrangement are not able to bind to nucleotides efficiently because of steric hindrance. Oxidation of Ni(cyclam) by KHSO5 to produce trivalent Ni-III (cyclam) improves the coordination capacity, while oxidation of NiCR does not produce a similar effect. The nucleotides interact with trivalent nickel complexes to different extent. Ni-III CR is seen to oxidize GMP gradually but does not affect AMP significantly. Ni-III (cyclam), on the other hand, does not oxidize either GMP or AMP at the 1: 1 concentration of oxidant used. This result is probably due to the lower redox potential of Ni(cyclam). ApG binds less efficiently to the Ni complexes but is easier oxidized than the mononucleotides. (C) 2002 Elsevier Science Inc. All rights reserved.
