Electrophysiologic effects of salbutamol, a β2-selective agonist
Electrophysiologic effects of salbutamol, a β2-selective agonist
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DOI：
10.1046/j.1540-8167.2004.03105.x
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发表时间：
2004-03-01
影响因子：
2.7
通讯作者：
Vallin, H
中科院分区：
文献类型：
--
作者：
Insulander, P;Juhlin-Dannfelt, A;Vallin, H
沙丁胺醇的电生理效应。简介：β 2刺激的正性变时作用是众所周知的。已经发表了β 2吸入治疗期间室性心律失常的病例报告。本研究的目的是评估β 2受体激动剂沙丁胺醇的总体电生理效应。方法和结果：在10名健康志愿者中，在基线心房起搏期间和以两种不同速率（0.1和0.2 μ g/kg/min）输注沙丁胺醇期间测量电生理和血液动力学变量。为了表征β（2）-激动剂的作用，与β（1）-选择性激动剂多巴酚丁胺进行了比较。沙丁胺醇输注在心肌和淋巴结组织中产生了显著的电生理特性变化，对淋巴结特性的影响显著更大。房室结参数的比例下降比窦房结更明显（P < 0.001）。一个有趣的结果是QS间期的持续时间显著增加，在存在不变的希氏-浦肯野传导（HV）的情况下，这表示心室的去极化较慢。QT离散度也增加。结论：输注沙丁胺醇对大多数心脏结构产生显著的电生理效应，在房室结中比例最明显。观察到对心室传导的不一致影响，心室传导减慢，心室肌不应期缩短。QT离散度增加。
Electrophysiologic Effects of Salbutamol. Introduction: A positive chronotropic effect of beta(2) stimulation is well known. Case reports of ventricular arrhythmias during beta(2)-inhalation therapy have been published. The aim of this study was to asses the overall electrophysiologic effects of the beta(2)-agonist salbutamol.Methods and Results: Ellectrophysiologic and hemodynamic variables were measured in 10 healthy volunteers during atrial pacing at baseline and during infusion of salbutamol at two different rates (0.1 and 0.2 mug/kg/min). To characterize beta(2)-agonist effects, a comparison was made with the beta(1)-selective agonist dobutamine. Salbutamol infusion produced significant changes in ellectrophysiologic properties in both myocardial and nodal tissues, with significantly greater effects on nodal properties. The proportional decreases in AV nodal parameters were more pronounced than in the sinus node (P < 0.001). An interesting result was a significant increase in the duration of the QS interval, which in the presence of an unchanged His-Purkinje conduction (HV) represents slower depolarization of the ventricle. QT dispersion also increased.Conclusion: Infusion of salbutamol results in significant ellectrophysiologic effects on most heart structures, proportionally most pronounced in the AV node. Discordant effects on ventricular conduction, which slowed, and the refractoriness of the ventricular myocardium, which shortened, were seen. QT dispersion was increased.