FACTORS IMPAIRING DAYTIME PERFORMANCE IN PATIENTS WITH SLEEP-APNEA HYPOPNEA SYNDROME
FACTORS IMPAIRING DAYTIME PERFORMANCE IN PATIENTS WITH SLEEP-APNEA HYPOPNEA SYNDROME
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DOI：
10.1001/archinte.152.3.538
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发表时间：
1992-03-01
影响因子：
--
通讯作者：
DOUGLAS, NJ
中科院分区：
文献类型：
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作者：
CHESHIRE, K;ENGLEMAN, H;DOUGLAS, NJ
患有睡眠呼吸暂停/低通气综合征的患者通常表现出日间表现受损。在一项前瞻性研究中，对29例睡眠呼吸暂停/低通气综合征患者进行多导睡眠图评估，以确定认知能力和日间嗜睡与睡眠中断、低氧血症和情绪的关系。认知功能的恶化与夜间呼吸不规则的严重程度、夜间低氧血症的程度和睡眠中断的程度显著相关。多元回归分析确定呼吸暂停加呼吸不足和觉醒的频率以及夜间低氧血症的程度是与认知缺陷最密切相关的变量。焦虑和抑郁也导致了这种损害。客观的白天嗜睡与夜间变量无显著相关性。这项研究表明，呼吸不规则的频率和睡眠中断和夜间低氧血症的程度在确定睡眠呼吸暂停/低通气综合征患者的日间功能方面很重要。在决定哪些患者需要治疗时，应考虑所有这些因素。
Patients with sleep apnea/hypopnea syndrome commonly demonstrate impaired daytime performance. In a prospective study, 29 patients with sleep apnea/hypopnea syndrome were assessed polysomnographically to determine the relationship of cognitive performance and daytime sleepiness with sleep disruption, hypoxemia, and mood. Deterioration of cognitive performance correlated significantly with increasing severity of nocturnal breathing irregularity, magnitude of nocturnal hypoxemia, and extent of sleep disruption. Multiple regression analysis identified frequency of apneas plus hypopneas and of arousal and the extent of nocturnal hypoxemia as the variables most strongly associated with cognitive deficits. Anxiety and depression also contributed to this impairment. Objective daytime sleepiness was not significantly associated with nocturnal variables. This study showed that the frequency of breathing irregularities and the extent of both sleep disruption and nocturnal hypoxemia are important in determining daytime function in patients with sleep apnea/hypopnea syndrome. All of these factors should be considered when deciding which patients require treatment.