Galectin-1 Is an Independent Prognostic Factor for Local Recurrence and Survival After Definitive Radiation Therapy for Patients With Squamous Cell Carcinoma of the Uterine Cervix
Galectin-1 Is an Independent Prognostic Factor for Local Recurrence and Survival After Definitive Radiation Therapy for Patients With Squamous Cell Carcinoma of the Uterine Cervix
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DOI：
10.1016/j.ijrobp.2013.08.037
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发表时间：
2013-12-01
影响因子：
7
通讯作者：
Huang, Chao-Cheng
中科院分区：
文献类型：
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作者：
Huang, Eng-Yen;Chanchien, Chan-Chao;Huang, Chao-Cheng
目的：探讨半乳糖凝集素-1在宫颈癌患者确定性放疗后的作用。方法和材料：我们回顾了154例国际妇产科联合会I-II期鳞状细胞癌。患者接受了治愈性放射治疗。使用半乳糖凝集素-1的免疫组织化学染色分析石蜡包埋的组织。在半乳糖凝集素-1无表达、弱表达和强表达的患者组织样本中比较癌症特异性生存率（CSS）、局部复发率（LR）和远处转移率。Kaplan-Meier法和考克斯比例风险模型的风险比和95%置信区间（CI）分别用于单变量和多变量analysis.Results：曲线下的面积半乳糖凝集素-1的细胞内表达分数LR和CSS均显着高于那些间质表达。在癌症组织样本中有和没有半乳糖凝集素-1细胞内表达的患者之间，人口统计学数据（如分期和血清肿瘤标志物）没有显著差异。使用多变量分析，LR和CSS的风险比分别为2.60（95%CI 1.50-4.52）（P= 0.001）和1.94（95%CI 1.18-3.19）（P= 0.010），foreign.Conclusion：Galectin-1是一个独立的预后因素与LR和CSS在I-II期宫颈癌患者接受明确的放射治疗。针对galectin-1的进一步研究可能会改善宫颈癌的局部控制。(C)2013 Elsevier Inc.
Purpose: To investigate the role of galectin-1 in patients with cervical cancer after definitive radiation therapy.Methods and Materials: We reviewed 154 patients with International Federation of Gynecology and Obstetrics stage I-II squamous cell carcinoma. Patients underwent curative-intent radiation therapy. Paraffin-embedded tissues were analyzed using immunohistochemistry staining for galectin-1. The rates of cancer-specific survival (CSS), local recurrence (LR), and distant metastasis were compared among patient tissue samples with no, weak, and strong galectin-1 expression. The Kaplan-Meier method and the Cox proportional hazard model with hazard ratios and 95% confidence intervals (CIs) were used for univariate and multivariate analyses, respectively.Results: The areas under the curve for the intracellular expression scores of galectin-1 for both LR and CSS were significantly higher than those for stromal expression. There were no significant differences in the demographic data, such as stage and serum tumor markers, between patients with and without intracellular expression of galectin-1 in cancer tissue samples. Using multivariate analyses, the hazard ratios of LR and CSS were 2.60 (95% CI 1.50-4.52) (P=.001) and 1.94 (95% CI 1.18-3.19) (P=.010), respectively.Conclusion: Galectin-1 is an independent prognostic factor associated with LR and CSS in stage I-II cervical cancer patients undergoing definitive radiation therapy. Further studies targeting galectin-1 may improve the local control of cervical cancer. (C) 2013 Elsevier Inc.