Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach
Iron-Catalyzed Methylation Using the Borrowing Hydrogen Approach
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DOI：
10.1021/acscatal.8b02158
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发表时间：
2018-06
期刊：
影响因子：
12.9
通讯作者：
Kurt Polidano;Benjamin D W Allen;Jonathan M. J. Williams;Louis C. Morrill
中科院分区：
文献类型：
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作者：
Kurt Polidano;Benjamin D W Allen;Jonathan M. J. Williams;Louis C. Morrill
一个通用的铁催化甲基化已经开发使用甲醇作为C1积木。这种借氢方法采用Knolker型（环己烯酮）铁羰基络合物作为催化剂（2摩尔%），并表现出宽的反应范围。各种酮、吲哚、羟吲哚、胺和磺酰胺以优异的分离产率（>60个实例，79%平均产率）进行单或二甲基化。
A general iron-catalyzed methylation has been developed using methanol as a C1 building block. This borrowing hydrogen approach employs a Knolker-type (cyclopentadienone)iron carbonyl complex as catalyst (2 mol %) and exhibits a broad reaction scope. A variety of ketones, indoles, oxindoles, amines, and sulfonamides undergo mono- or dimethylation in excellent isolated yields (>60 examples, 79% average yield).