Single reading with computer-aided detection for screening mammography
Single reading with computer-aided detection for screening mammography
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DOI：
10.1056/nejmoa0803545
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发表时间：
2008-10-16
影响因子：
158.5
通讯作者：
Duffy, Stephen W.
中科院分区：
文献类型：
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作者：
Gilbert, Fiona J.;Astley, Susan M.;Duffy, Stephen W.
背景：当两个阅读器读取乳房X光照片而不是一个阅读器读取乳房X光照片时，筛查乳房X光检查对小乳腺癌的检测灵敏度更高。我们进行了一项试验，以确定使用计算机辅助检测系统的单个阅读器的性能是否与两个阅读器的性能相匹配。方法：试验设计为等效性试验，将计算机辅助检测的单读数与双读数的癌症检测率进行配对比较。我们随机将31,057名在英国三个中心接受常规乳房X光检查的妇女按1：1：28的比例分配到双重阅读、计算机辅助检测的单一阅读或双重阅读和计算机辅助检测的单一阅读。结果：227例患者中，复读法阳性率为199例(87.7%)，单纯阅读加计算机辅助检测法阳性率为198例(87.2%)，两者差异有统计学意义(P=0.89)。计算机辅助检测重复阅读的总召回率为3.4%，单次阅读的召回率为3.9%，两者差异虽小，但差异有统计学意义(P
Background: The sensitivity of screening mammography for the detection of small breast cancers is higher when the mammogram is read by two readers rather than by a single reader. We conducted a trial to determine whether the performance of a single reader using a computer-aided detection system would match the performance achieved by two readers.Methods: The trial was designed as an equivalence trial, with matched-pair comparisons between the cancer-detection rates achieved by single reading with computer-aided detection and those achieved by double reading. We randomly assigned 31,057 women undergoing routine screening by film mammography at three centers in England to double reading, single reading with computer-aided detection, or both double reading and single reading with computer-aided detection, at a ratio of 1:1:28. The primary outcome measures were the proportion of cancers detected according to regimen and the recall rates within the group receiving both reading regimens.Results: The proportion of cancers detected was 199 of 227 (87.7%) for double reading and 198 of 227 (87.2%) for single reading with computer-aided detection (P=0.89). The overall recall rates were 3.4% for double reading and 3.9% for single reading with computer-aided detection; the difference between the rates was small but significant (P