MACROPHAGES RELATED TO BRUCHS MEMBRANE IN AGE-RELATED MACULAR DEGENERATION
MACROPHAGES RELATED TO BRUCHS MEMBRANE IN AGE-RELATED MACULAR DEGENERATION
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作者：
KILLINGSWORTH, MC;SARKS, JP;SARKS, SH
本报告描述了年龄相关性黄斑变性中布鲁赫膜的局灶性变薄，并提出了巨噬细胞在此过程中的作用。 电子显微镜下进行了四只眼睛，从正常老化到年龄相关性黄斑变性与早期视网膜下新生血管。 随着退变的进展，观察到Bruch膜的多个变薄节段，巨噬细胞似乎吞噬外部胶原区的片段。 在此阶段的相关发现是视网膜色素上皮脱落膜碎片及其在Bruch膜内沉积。 这种碎片形成了软性玻璃疣的基础，但在这种材料的存在下，在硬性玻璃疣下也观察到布鲁赫膜变薄。 这表明，广泛积累的含磷脂膜连同脂质的焦点浓度在硬玻璃疣吸引巨噬细胞。
This report describes focal thinning of Bruch's membrane in age-related macular degeneration and suggests a role for macrophages in this process. Electron microscopy was performed on four eyes ranging from normal ageing to age-related macular degeneration with early subretinal neovascularisation. As degeneration progressed multiple segments of thinning of Bruch's membrane were observed and macrophages appeared to engulf fragments of the outer collagenous zone. An associated finding at this stage was the shedding of membranous debris by the retinal pigment epithelium and its deposition within Bruch's membrane. This debris forms the basis of soft drusen but in the presence of this material thinning of Bruch's membrane was also observed beneath hard drusen. It is suggested that the widespread accumulation of phospholipid-containing membranes together with the focal concentration of lipid in hard drusen attract macrophages.