ROLE OF THE H-2-COMPLEX IN THE INDUCTION OF T-CELL TOLERANCE TO SELF MINOR HISTOCOMPATIBILITY ANTIGENS
ROLE OF THE H-2-COMPLEX IN THE INDUCTION OF T-CELL TOLERANCE TO SELF MINOR HISTOCOMPATIBILITY ANTIGENS
复制标题
DOI：
10.1084/jem.158.5.1483
复制
发表时间：
1983-01-01
影响因子：
15.3
通讯作者：
SINGER, A
中科院分区：
文献类型：
--
作者：
GROVES, ES;SINGER, A
细胞毒性T淋巴细胞（CTL）反应特异性的次要组织相容性（次要H）抗原被用来作为一种实验方法，以确定是否识别自身MHC [主要组织相容性复合体]决定簇参与诱导T细胞耐受自身抗原。C3H.SW脾T细胞来自C3H.SW →B10 ×B10.BR辐射骨髓嵌合体含有对自身C3 H次要H抗原+ H-2k反应的CTL前体（pCTL），但对自身C3 H次要H抗原+ H-2b耐受。观察到C3 H →具有相互反应性模式的前体CTL。B10 ×B10.BR嵌合体。C3H.SW胸腺细胞来自C3H.SW →B10. B10.BR嵌合体可产生少量H特异性CTL应答，并对自身C3 H少量H抗原+ H-2k具有反应性，但对自身C3 H少量H抗原+ H-2b具有耐受性。显然，对于外周和胸腺内T细胞群体，至少T细胞对自身抗原的耐受性的一个组成部分受到MHC产物的限制。
Cytotoxic T lymphocyte (CTL) responses specific for minor histocompatibility (minor H) antigens were used as an experimental approach to determine whether recognition of self MHC [major histocompatibility complex] determinants is involved in the induction of T cell tolerance to self antigens. C3H.SW splenic T cells from C3H.SW .fwdarw. B10 .times. B10.BR radiation bone marrow chimeras contained CTL precursors (pCTL) reactive against self C3H minor H antigens + H-2k, but were tolerant to self C3H minor H antigens + H-2b. Precursor CTL with the reciprocal reactivity pattern were observed for C3H .fwdarw. B10 .times. B10.BR chimeras. C3H.SW thymocytes from C3H.SW .fwdarw. B10 .RTM. B10.BR chimeras could generate minor H-specific CTL responses and were reactive against self C3H minor H antigens + H-2k, but were tolerant to self C3H minor H antigens + H-2b. Apparently, for peripheral and intrathymic T cell populations at least a component of T cell tolerance to self antigens is restricted by products of the MHC.