Post-spike hyperpolarization participates in the formation of auditory behavior-related response patterns of inferior collicular neurons in Hipposideros pratti
Post-spike hyperpolarization participates in the formation of auditory behavior-related response patterns of inferior collicular neurons in Hipposideros pratti
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DOI：
10.1016/j.neuroscience.2015.01.016
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发表时间：
2015-03
期刊：
影响因子：
3.3
通讯作者：
Y.-L. Li;Z. Fu;M.-J. Yang;J. Wang;K. Peng;L. Yang;J. Tang;Q.-C. Chen
中科院分区：
文献类型：
--
作者：
Y.-L. Li;Z. Fu;M.-J. Yang;J. Wang;K. Peng;L. Yang;J. Tang;Q.-C. Chen
为探讨普氏蹄蝠下丘神经元对恒定频率-频率调制（CF-FM）刺激的听觉行为相关反应模式的形成机制，我们研究了脉冲后超极化（PSH）在反应模式形成中的作用。通过在体细胞外（N= 145）和细胞内（N= 171）记录获得的神经元可一致地分为单on（SO）和双on（DO）神经元。利用细胞内记录，我们发现SO和DO神经元都有不同持续时间的PSH。统计学分析表明，大多数SO神经元的PSH持续时间比DO神经元长（p< 0.01）。这些结果表明，PSH直接参与SO和DO神经元的形成，CF成分诱发的PSH是SO和DO反应模式的主要突触机制。这些研究结果有关蝙蝠回声定位可能的生物学意义进行了讨论。
To probe the mechanism underlying the auditory behavior-related response patterns of inferior collicular neurons to constant frequency–frequency modulation (CF–FM) stimulus inHipposideros pratti, we studied the role of post-spike hyperpolarization (PSH) in the formation of response patterns. Neurons obtained byin vivoextracellular (N= 145) and intracellular (N= 171) recordings could be consistently classified into single-on (SO) and double-on (DO) neurons. Using intracellular recording, we found that both SO and DO neurons have a PSH with different durations. Statistical analysis showed that most SO neurons had a longer PSH duration than DO neurons (p< 0.01). These data suggested that the PSH directly participated in the formation of SO and DO neurons, and the PSH elicited by the CF component was the main synaptic mechanism underlying the SO and DO response patterns. The possible biological significance of these findings relevant to bat echolocation is discussed.