Application of N,N-dimethylformamide dineopentyl acetal for efficient anchoring of N alpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis.
Application of N,N-dimethylformamide dineopentyl acetal for efficient anchoring of N alpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis.
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N,N-二甲基甲酰胺二新戊基缩醛在固相肽合成中有效锚定 N α-9-芴基甲氧基羰基氨基酸作为对烷氧基苄基酯的应用。
DOI：
10.1111/j.1399-3011.1984.tb02729.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Barany,G
中科院分区：
文献类型：
--
作者：
Albericio,F;Barany,G
通过 DCC-DMAP 偶联将 Fmoc-氨基酸附着在烷氧基苯甲醇树脂上遇到两个不同的问题：二聚体的形成和外消旋化。使用N,N-二甲基甲酰胺二新戊基缩醛制备Fmoc-氨基酰氧基苄基手柄是安全有效的锚定方法的基础，可以避免这两个问题。
The attachment of Fmoc‐amino acids ontop‐alkoxybenzyl alcohol resinsviaDCC‐DMAP coupling suffers from two different problems: formation of dimers and racemization. The use ofN,N‐dimethylformamide dineopentyl acetal for the preparation of Fmoc‐aminoacyloxybenzyl handles is the basis of a safe and efficient anchoring method that avoids both problems.