HISTOLOGIC AND HEMODYNAMIC CORRELATES OF RIGHT VENTRICULAR FUNCTION IN A PRESSURE OVERLOAD MODEL: A STUDY USING THREE-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY
HISTOLOGIC AND HEMODYNAMIC CORRELATES OF RIGHT VENTRICULAR FUNCTION IN A PRESSURE OVERLOAD MODEL: A STUDY USING THREE-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY
复制标题
压力过载模型中右心室功能的组织学和血流动力学相关性：使用三维斑点跟踪超声心动图的研究
DOI：
10.1016/j.ultrasmedbio.2017.09.022
复制
发表时间：
2018-02-01
影响因子：
2.9
通讯作者：
Xie, Mingxing
中科院分区：
文献类型：
--
作者：
Li, Yuman;Li, Lei;Xie, Mingxing
本研究的目的是评价三维斑点追踪超声心动图(STE)在慢性右室压力超负荷动物模型中的右室变形特征，以及3D-STE指数与组织学和血流动力学参数的关系。采用肺动脉结扎法(PAB)复制7只比格犬右室压力超负荷模型。PAB后3个月行3D-STE、组织学和血流动力学检测。3D-STE测量右室纵向、径向和周向应变。PAB后3个月，PAB组RV纵向应变减小，而径向和周向应变无明显变化。在右室游离壁的心内膜层，右室纵向应变与间质纤维化相关(r=-0.733)。右室周向应变与dp/dtmax呈正相关(r=0.718)。RV 3D-STE指数与组织学和血流动力学参数的相关性表明，3D-STE可能是评价RV压力超负荷时心功能的一种有价值的工具。(电子邮件：xiemx64@126.com)(C)2018由爱思唯尔公司代表世界超声医学与生物学联合会发布。
The aim of our study was to assess the characterization of right ventricular (RV) deformation using three-dimensional (3D) speckle tracking echocardiography (STE) and association of 3D-STE indices with histologic and hemodynamic parameters in a chronic RV pressure overload animal model. Pulmonary artery banding (PAB) was used to induce RV pressure overload in seven beagles. 3D-STE, histologic and hemodynamic measurements were performed in PAB and sham-operated beagles 3 mo after PAB. RV longitudinal, radial and circumferential strain was measured from 3D-STE. Three mo after PAB, RV longitudinal strain was decreased; whereas radial and circumferential strain remained unchanged in PAB group. RV longitudinal strain was associated with interstitial fibrosis (r = -0.733) in the endocardial layer of the RV free wall. RV circumferential strain was related to dp/dtmax (r = 0.718). The significant correlations of RV 3D-STE indices with histologic and hemodynamic parameters indicate that 3D-STE may be a valuable tool for assessment of ventricular function in RV pressure overload. (E-mail: xiemx64@126.com) (C) 2018 Published by Elsevier Inc. on behalf ofWorld Federation for Ultrasound in Medicine & Biology.