The incidence of Parkinson's disease in the North-East of England
The incidence of Parkinson's disease in the North-East of England
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DOI：
10.1093/ageing/aft091
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发表时间：
2014-03-01
期刊：
影响因子：
6.7
通讯作者：
Burn, David J.
中科院分区：
文献类型：
--
作者：
Duncan, Gordon William;Khoo, Tien Kheng;Burn, David J.
背景：帕金森病是老年人的常见病。准确的流行病学信息对于确定可能的病因、规划卫生服务和确定医学研究的优先事项至关重要。目的：确定特发性帕金森病在英格兰东北部特定地理区域的发病率。方法：采用前瞻性纵向设计，我们试图确定在英格兰东北部纽卡斯尔和盖茨黑德地区出现的每一例帕金森病新病例。基础人群包括488 576人，采用了多种病例确定来源。2009年6月1日至2011年5月31日期间所有新诊断的特发性帕金森病或帕金森症患者被邀请参与研究。患者由专科医生检查，并进行纵向随访，以便进行诊断性复查。结果：我们确定了257例潜在病例，其中181例疑似特发性帕金森病。在18个月的随访期后，155名患者保留了可能的帕金森病的临床诊断。诊断时的平均年龄为72.4±10岁。纽卡斯尔和盖茨黑德的PD粗发病率为每年每10万人15.9例（95% CI: 13.4-18.4）。欧洲人群年龄标准化后帕金森病的发病率为12.0 / 10万（95% CI: 10.1-14.0）。我们发现男性的粗发病率为17.7 / 10万（95% CI: 14.0-21.4）高于女性的14.0 / 10万（95% CI: 10.7-17.4）。结论：在本前瞻性纵向研究中，英格兰东北部帕金森病的发病率与其他现代欧美研究相似。
Background: Parkinson's disease is a common disorder among older people. Accurate epidemiological information is essential to identify possible aetiological factors, plan health services and set priorities for medical research.Objective: to determine the incidence of idiopathic Parkinson's disease in a defined geographical area in the North-East of England.Methods: using a prospective, longitudinal design, we sought to identify every new case of Parkinson's disease arising in the Newcastle and Gateshead area in the North-East of England. The base population comprised 488 576 individuals and multiple sources of case ascertainment were employed. All the patients with newly diagnosed idiopathic Parkinson's disease or parkinsonism between 1 June 2009 and 31 May 2011 were invited to participate. Patients were examined by a specialist and followed longitudinally to permit diagnostic review.Results: we identified 257 potential cases, of whom 181 had suspected idiopathic Parkinson's disease. After a follow-up period of 18 months, 155 patients retained a clinical diagnosis of probable Parkinson's disease. The mean age at diagnosis was 72.4 +/- 10 years. The crude incidence of PD in Newcastle and Gateshead was 15.9 per 100 000 persons per year (95% CI: 13.4-18.4). Age-standardised to the European population the incidence of Parkinson's disease was 12.0 per 100 000 (95% CI: 10.1-14.0). We found a higher crude incidence among men 17.7 per 100 000 (95% CI: 14.0-21.4) than women 14.0 per 100 000 (95% CI: 10.7-17.4).Conclusion: in this prospective longitudinal study, the incidence rate of Parkinson's disease in North-East England is similar to that of other modern European and American studies.