Voxel-wise assessment of progression of regional brain atrophy in relapsing-remitting multiple sclerosis
Voxel-wise assessment of progression of regional brain atrophy in relapsing-remitting multiple sclerosis
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DOI：
10.1016/j.jns.2009.02.322
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发表时间：
2009-07-15
影响因子：
4.4
通讯作者：
De Stefano, Nicola
中科院分区：
文献类型：
--
作者：
Battaglini, Marco;Giorgio, Antonio;De Stefano, Nicola
目的：对复发缓解型 (RR) 多发性硬化症 (MS) 受试者的局部脑萎缩状态和发生率进行体素评估。背景：最近，人们的注意力集中在定义发生脑萎缩的组织区室和区域上。这些脑容量变化的区域测量可能有助于更好地确定多发性硬化症的病理本质。在这种情况下，可以通过使用基于体素的形态测量 (VBM) 方法获得灰质 (GM) 体积变化的特定区域测量值。方法：59 名 RR MS 受试者在基线时和平均随访 3 年后接受了常规 MRI。进行了两项 VBM 横断面分析（SPM-VBM，基于统计参数映射软件包，FSL-VBM，基于 FMRIB 软件库工具），以评估 RR MS 患者与 25 名年龄和性别匹配的正常对照 (NC) 相比的皮质 GM 体积。纵向上，FSL-VBM 和 SIENA 方法的区域延伸（SIENAr）均用于评估 RR MS 患者的区域脑萎缩率及其与随访期间 T-2 加权白质（WM）病变体积增加的关系。结果：与 NC 相比，RR MS 患者的皮质 CM 体积广泛减少。 SPM-VBM 和 FSL-VBM 均显示出相似的皮质区域受累情况（额叶、颞叶、顶叶、枕叶和岛叶），两种不同程序获得的显着体素数量之间存在密切相关性（r=0.73，p
Objective: To perform voxel-wise assessments of regional brain atrophy state and rate in subjects with relapsing-remitting (RR) Multiple sclerosis (MS).Background: Recently, attention has focused on defining the tissue compartments and regions within which brain atrophy occurs. These regional measures of brain volume changes may help to better define the nature of the pathology underlying MS. In this context, specific regional measures of grey matter (GM) volume changes can be obtained by using the voxel-based morphometry (VBM) approach.Methods: Fifty-nine subjects with RR MS underwent conventional MRI at baseline and after a mean follow-up period of 3 years. Cross-sectionally, two VBM analyses (SPM-VBM, based on the Statistical Parametric Mapping software package, and FSL-VBM, based on the FMRIB Software Library tools) were performed to assess cortical GM volumes in RR MS patients compared to 25 age- and sex-matched normal controls (NC). Longitudinally, FSL-VBM and the regional extension of the SIENA method (SIENAr) were both used to assess regional brain atrophy rate in the RR MS patients and its relationship with increases in T-2-weighted white matter (WM) lesion volume over the follow-up period.Results: Widespread decrease in cortical CM volume was found in the RR MS patients compared to NC. Both SPM-VBM and FSL-VBM showed similar involvement of cortical regions (frontal, temporal, parietal, occipital lobes and insula), with a close correlation between the numbers of significant voxels obtained with the two different procedures (r=0.73, p