Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection.
Exploring the Role of Low-Density Neutrophils During Mycobacterium tuberculosis Infection.
复制标题
DOI：
10.3389/fcimb.2022.901590
复制
发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
--
作者：
结核病（TB）是由结核分枝杆菌（Mtb）感染引起的，它主要感染肺部，但也可引起肺外疾病。结核病的疾病结果和病理学都是由宿主产生的免疫反应驱动的。Mtb感染激发了控制感染所必需的炎症宿主反应，但当过量时也可引起广泛的组织损伤，因此必须精确平衡。特别是，中性粒细胞过度募集到感染部位与结核分枝杆菌感染控制不良有关，促使对中性粒细胞在结核病结局中的作用进行调查。最近的研究表明，嗜中性粒细胞可以分为亚群，在结核病状态下差异丰富，突出了潜在的复杂性，在确定嗜中性粒细胞在结核分枝杆菌感染的作用。具体地，基于在密度梯度离心和表面标志物表达期间中性粒细胞的分离，可以将中性粒细胞分离成正常（NDN）和低密度中性粒细胞（LDN）。LDN在活动性TB疾病期间以更高的数量存在，并且随着疾病进展而增加频率，尽管它们对TB的直接贡献仍然未知。此外，LDN的丰度也与其他肺部感染的严重程度相关，包括COVID-19。在这篇综述中，我们讨论了LDN在肺部炎症过程中的作用，强调其与结核病结局的关系。这篇综述强调了未来研究中性粒细胞多样性与结核病严重程度之间关系的重要性。
Tuberculosis (TB) is caused by infection with the bacterium Mycobacterium tuberculosis (Mtb), which primarily infects the lungs but can also cause extrapulmonary disease. Both the disease outcome and the pathology of TB are driven by the immune response mounted by the host. Infection with Mtb elicits inflammatory host responses that are necessary to control infection, but can also cause extensive tissue damage when in excess, and thus must be precisely balanced. In particular, excessive recruitment of neutrophils to the site of infection has been associated with poor control of Mtb infection, prompting investigations into the roles of neutrophils in TB disease outcomes. Recent studies have revealed that neutrophils can be divided into subpopulations that are differentially abundant in TB disease states, highlighting the potential complexities in determining the roles of neutrophils in Mtb infection. Specifically, neutrophils can be separated into normal (NDN) and low-density neutrophils (LDNs) based on their separation during density gradient centrifugation and surface marker expression. LDNs are present in higher numbers during active TB disease and increase in frequency with disease progression, although their direct contribution to TB is still unknown. In addition, the abundance of LDNs has also been associated with the severity of other lung infections, including COVID-19. In this review, we discuss recent findings regarding the roles of LDNs during lung inflammation, emphasizing their association with TB disease outcomes. This review highlights the importance of future investigations into the relationship between neutrophil diversity and TB disease severity.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Askling, J;Fored, CM;Feltelius, N
通讯作者：
Feltelius, N
影响因子：
5.4
作者：
Dorhoi, Anca;Yeremeev, Vladimir;Kaufmann, Stefan H. E.
通讯作者：
Kaufmann, Stefan H. E.
DOI：
10.1164/rccm.201302-0249oc
发表时间：
2013-09-15
影响因子：
24.7
作者：
du Plessis, Nelita;Loebenberg, Laurianne;Walzl, Gerhard
通讯作者：
Walzl, Gerhard
影响因子：
6.7
作者：
Cabrera LE;Pekkarinen PT;Alander M;Nowlan KHA;Nguyen NA;Jokiranta S;Kuivanen S;Patjas A;Mero S;Pakkanen SH;Heinonen S;Kantele A;Vapalahti O;Kekäläinen E;Strandin T
通讯作者：
Strandin T