Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii
Hypocrol A, a new tyrosol derivative from a sponge-derived strain of the fungus Hypocrea koningii
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Hypocrol A，一种来自海绵衍生真菌 Hypocrea koningii 菌株的新型酪醇衍生物
DOI：
10.1080/14786419.2015.1129333
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Xu, Shi-Hai
中科院分区：
文献类型：
--
作者：
Ding, Li-Jian;Yuan, Wei;Xu, Shi-Hai
摘要为了从海绵真菌中寻找新的抗菌和抗氧化代谢产物，从康氏肉座菌PF 04中分离得到一种新的酪醇衍生物hypocrol A（1），以及四种已知的同类物：麦角烯醇B（2），4-羟基苯乙基乙酸酯（3），4-羟基苯乙基十四烷酸酯（4）和1-油基酪醇（5）。它们的平面结构通过光谱方法和与文献数据的比较明确地阐明。所有化合物对金黄色葡萄球菌、耐甲氧西林葡萄球菌和耐甲氧西林葡萄球菌均表现出较弱的抗菌活性。金黄色葡萄球菌和大肠杆菌，而化合物1和2在DPPH（2，2-二苯基-1-苦基肼基）自由基清除试验中表现出中等的抗氧化功效，IC 50值分别为48.5和97.4 μg/mL。图形摘要
Abstract In continuation of our search for new antibacterial and antioxidant metabolites from sponge-derived fungi, one new tyrosol derivative, hypocrol A (1), together with four known congeners, trichodenol B (2), 4-hydroxyphenethyl acetate (3), 4-hydroxyphenethyl tetradecanoate (4) and 1-oleyltyrosol (5), was isolated from the strain Hypocrea koningii PF04. Their planar structures were unequivocally elucidated by spectroscopic methods and comparison with the literature data. All the compounds displayed weak antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus and Escherichia coli, whereas compounds 1 and 2 exhibited a moderate antioxidant efficacy in the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay with IC50 values of 48.5 and 97.4 μg/mL, respectively. Graphical abstract