Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women
Variation in the ciliary neurotrophic factor gene and muscle strength in older Caucasian women
复制标题
DOI：
10.1111/j.1532-5415.2006.00693.x
复制
发表时间：
2006-05-01
影响因子：
6.3
通讯作者：
Walston, Jeremy
中科院分区：
文献类型：
--
作者：
Arking, Dan E.;Fallin, Daniele M.;Walston, Jeremy
目的：确定睫状神经营养因子基因的遗传变异是否与老年女性的肌肉力量有关。设计：对女性健康和老龄化研究1(1992年)和11(1994年)的基线数据进行横断面分析，这是一项基于人群的互补性研究。设置：位于马里兰巴尔的摩的12个连续的邮政编码区域。样本：363名高加索社区居住的70岁至79岁的女性。测量：参与者在睫状神经营养因子基因座上8个单核苷酸多态(SNPs)的基因分型，包括零等位基因rs1.800169。因变量是握力和虚弱综合征，确定为五个虚弱指标中的三个或三个以上(虚弱、缓慢、体重减轻、低体力活动、精疲力竭)。结果：通过多元线性回归分析，发现5个SNP与握力显著相关(P
OBJECTIVES: To determine whether genetic variants in the ciliary neurotrophic factor (CNTF) gene are associated with muscle strength in older women.DESIGN: Cross-sectional analysis of baseline data from the Women's Health and Aging Studies 1 (1992) and 11 (1994), complementary population-based studies.SETTING: Twelve contiguous ZIP code areas in Baltimore, Maryland.PARTICIPANTS: Three hundred sixty-three Caucasian, community-dwelling women aged 70 to 79.MEASUREMENTS: Participants were genotyped at the CNTF locus for eight single nucleotide polymorphisms (SNPs), including the null allele rs1.800169. The dependent variables were grip strength and the frailty syndrome, identified as presence of three or more of five frailty indicators (weakness, slowness, weight loss, low physical activity, exhaustion). In addition to genotypes, independent variables of body mass index (BMI) and osreoarrhritis of the hands were included.RESULTS: Using multivariate linear regression, single SNP analysis identified five SNPs significantly associate with grip strength (P