Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.
Making genomic medicine evidence-based and patient-centered: a structured review and landscape analysis of comparative effectiveness research.
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DOI：
10.1038/gim.2017.21
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Douglas MP
中科院分区：
文献类型：
--
作者：
Phillips KA;Deverka PA;Sox HC;Khoury MJ;Sandy LG;Ginsburg GS;Tunis SR;Orlando LA;Douglas MP
Comparative effectiveness research (CER) in genomic medicine (GM) measures the clinical utility of using genomic information to guide clinical care in comparison to appropriate alternatives. We summarized findings of high-quality systematic reviews that compared the analytic and clinical validity and clinical utility of GM tests. We focused on clinical utility findings to summarize CER-derived evidence about GM and identify evidence gaps and future research needs. We abstracted key elements of study design, GM interventions, results, and study quality ratings from 21 systematic reviews published in 2010 through 2015. More than half (N = 13) of the reviews were of cancer-related tests. All reviews identified potentially important clinical applications of the GM interventions, but most had significant methodological weaknesses that largely precluded any conclusions about clinical utility. Twelve reviews discussed the importance of patient-centered outcomes, although few described evidence about the impact of genomic medicine on these outcomes. In summary, we found a very limited body of evidence about the effect of using genomic tests on health outcomes and many evidence gaps for CER to address. Genet Med advance online publication 13 April 2017
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DOI：
10.1056/nejmoa1310669
发表时间：
2013-12-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kimmel SE;French B;Kasner SE;Johnson JA;Anderson JL;Gage BF;Rosenberg YD;Eby CS;Madigan RA;McBane RB;Abdel-Rahman SZ;Stevens SM;Yale S;Mohler ER 3rd;Fang MC;Shah V;Horenstein RB;Limdi NA;Muldowney JA 3rd;Gujral J;Delafontaine P;Desnick RJ;Ortel TL;Billett HH;Pendleton RC;Geller NL;Halperin JL;Goldhaber SZ;Caldwell MD;Califf RM;Ellenberg JH;COAG Investigators
通讯作者：
COAG Investigators
DOI：
10.1038/gim.2013.73
发表时间：
2013-07
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
158.5
作者：
Cardoso, F.;van't Veer, L. J.;Piccart, M.
通讯作者：
Piccart, M.
影响因子：
8.8
作者：
Gregg, Anthony R.;Skotko, Brian G.;Watson, Michael S.
通讯作者：
Watson, Michael S.
影响因子：
8.8
作者：
Deverka, Patricia;Messner, Donna A.;Tunis, Sean R.
通讯作者：
Tunis, Sean R.