Correlation of mechanical properties within the equine third metacarpal with trabecular bending and multi-density micro-computed tomography data.
Correlation of mechanical properties within the equine third metacarpal with trabecular bending and multi-density micro-computed tomography data.
复制标题
马第三掌骨内的机械性能与小梁弯曲和多密度微计算机断层扫描数据的相关性。
DOI：
10.1016/j.bone.2010.01.366
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发表时间：
2010
期刊：
影响因子：
4.1
通讯作者：
Puttlitz,ChristianM
中科院分区：
文献类型：
--
作者：
Leahy,PDevin;Smith,BarbaraS;Easton,KatrinaL;Kawcak,ChrisE;Eickhoff,JensC;Shetye,SnehalS;Puttlitz,ChristianM
计算机断层扫描（CT）数据可用于确定机械性能，并已用于预测完整骨的弹性模量、屈服强度和最终强度等参数。微计算机断层扫描（μCT）具有极高的分辨率，能够检测到极局部区域的表观骨密度，并能表征小梁结构。有人认为这种微观结构易受微屈曲和弯曲的影响，这在预测骨的整体力学性能方面存在争议。本研究测量了马第三掌骨远端相对高表观密度骨的力学特性。力学性能与μCT测得的小梁形态参数和局部区域表观密度相关。这些数据用于验证两个假设：(1)使用小梁形态参数计算小梁弯曲比仅使用表观密度提供更好的整体力学性能预测；(2)低表观密度区域主导整体力学行为，与高表观密度区域相比，与测量的力学性能具有更大的相关性。数据表明，与仅依赖于表观密度的相关性相比，形态学参数对小梁弯曲的影响与力学性能的相关性更强（r2= 0.91 vs r2= 0.81）。与高表观密度区域相比，低表观密度区域与机械性能的相关性更强（r2= 0.85 vs r2= 0.77），这表明在试图从CT数据中预测机械性能时选择适当区域的重要性。
Computed tomography (CT) data can be employed with respect to determining mechanical properties and has been used to predict parameters such as elastic modulus, yield strength, and ultimate strength of intact bone. Micro-computed tomography (μCT) possesses the resolution capable of detecting apparent bone density in extremely local regions and can characterize the trabecular structure. It has been asserted that this micro-structure is susceptible to micro-buckling and bending, which has a controversial role in predicting the global mechanical properties of bone. The current study measured the mechanical properties of relatively high apparent density bone from the equine distal third metacarpal. The mechanical properties were correlated with trabecular morphology parameters and apparent densities of localized regions obtained with μCT. These data were used to test two hypotheses: (1) accounting for trabecular bending using trabecular morphology parameters would provide better global mechanical property predictions than using only apparent density, and (2) regions of low apparent density dominate the overall mechanical behavior and provide greater correlation to the measured mechanical properties than regions of high apparent density. The data indicated that accounting for trabecular bending with morphological parameters resulted in stronger correlations to mechanical properties than correlations that relied only on apparent density (r2= 0.91 versus r2= 0.81). Low apparent density regions were more strongly correlated with mechanical properties than high apparent density regions (r2= 0.85 versus r2= 0.77), demonstrating the importance of selecting appropriate regions when attempting to predict mechanical properties from CT data.