Blood pressure and end-stage renal disease in men
Blood pressure and end-stage renal disease in men
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DOI：
10.1056/nejm199601043340103
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发表时间：
1996-01-04
影响因子：
158.5
通讯作者：
Stamler, J
中科院分区：
文献类型：
--
作者：
Klag, MJ;Whelton, PK;Stamler, J
背景：在美国，终末期肾病对个人和整个社会都造成了巨大的负担，预防这种疾病的努力需要了解可改变的危险因素。我们评估了332,544名年龄在35岁至57岁之间的男性在1990年的终末期肾脏疾病的发展情况，他们在1973至1975年间接受了多风险因素干预试验(MRFIT)的筛查。我们使用了来自卫生保健筹资管理局的国家终末期肾病治疗登记处的数据，以及来自国家死亡指数和社会保障管理局的肾脏疾病死亡记录的数据。在平均16年的随访中，814名受试者死于终末期肾脏疾病或接受治疗(每10万人年观察15.6例)，发现收缩和舒张压与终末期肾脏疾病之间存在强烈的分级关系，而与疾病与年龄、种族、收入、糖尿病药物使用、心肌梗塞病史、血清胆固醇浓度和吸烟之间的关系无关。与具有最佳血压水平(收缩压)的男性相比
Background, End-stage renal disease in the United States creates a large burden for both individuals and society as a whole, Efforts to prevent the condition require an understanding of modifiable risk factors.Methods. We assessed the development of end-stage renal disease through 1990 in 332,544 men, 35 to 57 years of age, who were screened between 1973 and 1975 for entry into the Multiple Risk Factor Intervention Trial (MRFIT). We used data from the national registry for treated end-stage renal disease of the Health Care Financing Administration and from records on death from renal disease from the National Death Index and the Social Security Administration.Results. During an average of 16 years of follow-up, 814 subjects either died of end-stage renal disease or were treated for that condition (15.6 cases per 100,000 person-years of observation), A strong, graded relation between both systolic and diastolic blood pressure and end-stage renal disease was identified, independent of associations between the disease and age, race, income, use of medication for diabetes mellitus, history of my-ocardial infarction, serum cholesterol concentration, and cigarette smoking. As compared with men with an optimal level of blood pressure (systolic pressure