Tumor macrophages as a target for Capsaicin mediated immunotherapy
Tumor macrophages as a target for Capsaicin mediated immunotherapy
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DOI：
10.1016/j.canlet.2012.05.002
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发表时间：
2012-11-01
期刊：
影响因子：
9.7
通讯作者：
Basu, Sreyashi
中科院分区：
文献类型：
--
作者：
Ghosh, Amiya K.;Basu, Sreyashi
肿瘤微环境在很大程度上导致了抗原性肿瘤免疫破坏的失败。大多数实体瘤适应微环境并逃避宿主免疫系统。神经免疫配体辣椒素(CP)在实体瘤消退中的戏剧性和全身性效果使我们研究了它在肿瘤微环境中的免疫调节作用。在这篇报告中，我们证明了CP诱导的肿瘤细胞凋亡导致周围间质的增敏，表现为间质巨噬细胞的抗原提呈增强，并被肿瘤特异性T细胞破坏。此外，CP注射改变了肿瘤微环境，包括肿瘤浸润性Treg细胞以及肿瘤部位的细胞因子环境。我们的数据共同证明，注射CP启动了几个独立的先天和获得性免疫事件的级联，在肿瘤环境中启动。爱思唯尔爱尔兰有限公司出版。
Tumor microenvironment contributes to a large extent for failure of immunological destruction of antigenic tumors. Most solid tumors adapt to the microenvironment and escape the host immune system. The dramatic and systemic effectiveness of neuro-immune ligand Capsaicin (CP) in regression of established solid tumors led us to investigate its immunomodulatory role in tumor microenvironment. In this report we demonstrate that CP induced tumor cell apoptosis leads to increased sensitization of the surrounding stroma manifested by enhanced antigen presentation by stromal macrophages and its destruction by tumor specific T-cells. Further, CP injection alters the tumor microenvironment with regards to tumor-infiltrating Treg cells as well as the cytokine milieu at the tumor site. Our data collectively demonstrates that injection of CP sets in motion, a cascade of several independent innate and adaptive immunological events initiated at the tumor environment. Published by Elsevier Ireland Ltd.