ALTERNATIVE SPLICING OF MOUSE-BRAIN 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE MESSENGER-RNA
ALTERNATIVE SPLICING OF MOUSE-BRAIN 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE MESSENGER-RNA
复制标题
DOI：
10.1016/0006-291x(90)90502-e
复制
发表时间：
1990-08-16
影响因子：
3.1
通讯作者：
TAKAHASHI, Y
中科院分区：
文献类型：
--
作者：
KURIHARA, T;MONOH, K;TAKAHASHI, Y
分离了小鼠脑2“，3”-环核苷酸3“-磷酸二酯酶（cDNA II）的第二个cDNA，其编码420个氨基酸。与之前获得的编码400个氨基酸的cDNA（cDNAI）的唯一区别是5 ''端53个碱基对。小鼠基因序列与cDNA II序列的比较表明外显子1内存在选择性剪接。cDNA II的5“-末端序列被发现在外显子1的基因上游的区域中，并且鉴定了第二个转录起始位点。
A second cDNA for mouse brain 2'',3''-cyclic-nucleotide 3''-phosphodiesterase (cDNAII) encoding 420 amino acids was isolated. The only difference from the cDNA obtained previously (cDNAI), which encodes 400 amino acids, was the 5''-end 53 bp. Comparison of the sequence of the mouse gene with the sequence of cDNAII indicates alternative splicing within exon 1. The 5''-end sequence of cDNAII was found in a region of the gene upstream of exon 1 and a second transcription initiation site was identified.