Synthesis, characterization, electrochemistry and evaluation of biological activities of some ferrocenyl Schiff bases
Synthesis, characterization, electrochemistry and evaluation of biological activities of some ferrocenyl Schiff bases
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DOI：
10.1002/aoc.1690
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发表时间：
2011
影响因子：
3.9
通讯作者：
Muhammad Zaheer;Afzal Shah;Z. Akhter;R. Qureshi;B. Mirza;Misbah Tauseef;M. Bolte
中科院分区：
文献类型：
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作者：
Muhammad Zaheer;Afzal Shah;Z. Akhter;R. Qureshi;B. Mirza;Misbah Tauseef;M. Bolte
通过4-二茂铁基苯胺与不同取代的芳香醛和乙酰丙酮的缩合反应合成二茂铁基希夫碱(1-6)。通过物理测量、元素分析、FT-IR、1H-NMR 和 13C-NMR 光谱对化合物进行表征。化合物 2 的单晶 X 射线分析显示两个通过 C-N 双键连接的芳环共面。化合物表现出可逆的单电子氧化还原行为，并且发现它们的峰值电流随着扫描速率ν1/2的平方根线性增加。发现整个电极过程是扩散控制的。化合物 1 和 4 显示出低细胞毒性和显着的抗真菌、抗氧化和 DNA 保护活性。版权所有 © 2010 约翰威利父子有限公司
Synthesis of ferrocenyl Schiff bases (1–6) was carried out by the condensation reaction of 4-ferrocenyl aniline with different substituted aromatic aldehydes and acetyl acetone. Compounds were characterized by physical measurements, elemental analysis, FT-IR, 1H-NMR and 13C-NMR spectroscopy. Single crystal X-ray analysis of compound 2 showed the co-planarity of both aromatic rings connected by a C–N double bond. Compounds demonstrated reversible one-electron redox behavior and their peak currents were found to increase linearly with the square root of the sweep rate ν1/2. The overall electrode processes were found to be diffusion controlled. Compounds 1 and 4 showed low cytotoxicity and appreciable antifungal, antioxidant and DNA protection activities. Copyright © 2010 John Wiley & Sons, Ltd.