Complement genomics and antibody-mediated rejection in heart recipients
Complement genomics and antibody-mediated rejection in heart recipients
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DOI：
10.1016/j.healun.2017.08.008
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发表时间：
2018-04-01
影响因子：
8.9
通讯作者：
Carbone, Javier
中科院分区：
文献类型：
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作者：
Carbone, Javier
在本期《心肺移植杂志》中，Marron-Linares 等人报告了一项有趣的研究结果，他们评估了少数心脏受者体内与补体途径相关的 51 个基因，以探索它们与抗体介导的排斥反应 (AMR) 的关系。新一代测序应用于 46 名心脏移植受者（23 名有 AMR，23 名无 AMR）。作者确定了 2 个单核苷酸多态性与 AMR 的缺失或存在显着相关，分别是甘露糖结合凝集素 (MBL) 2 基因中的 p.Gly54Asp-MBL2 和替代补体因子备解素 (CFP) 基因中的 p.Asn428(p=)-CFP。本文是对心脏移植文献的新贡献。这表明补体单核苷酸多态性可能影响凝集素途径和替代补体途径的选定蛋白质的循环水平，从而可能决定哪些患者将出现 AMR。 (C) 2018 年国际心肺移植学会。版权所有。
In this issue of the Journal of Heart and Lung Transplantation, Marron-Linares et al report the results of an interesting study in which they evaluated 51 genes associated with the complement pathway in a small number of heart recipients to explore their relationship with antibody-mediated rejection (AMR). Next-generation sequencing was used in 46 heart transplant recipients (23 with AMR and 23 without AMR). The authors identified a significant association of 2 single-nucleotide polymorphisms with the absence or presence of AMR, respectively, p.Gly54Asp-MBL2 in the mannose-binding lectin (MBL) 2 gene and p.Asn428(p=)-CFP in the alternative complement factor properdin (CFP) gene. This article is a new contribution to the heart transplant literature. It suggests that complement single-nucleotide polymorphisms may influence circulating levels of selected proteins of both the lectin pathway and alternative complement pathways, thus potentially determining which patients will develop AMR. (C) 2018 International Society for Heart and Lung Transplantation. All rights reserved.