Effect of influenza vaccine on markers of inflammation and lipid profile
Effect of influenza vaccine on markers of inflammation and lipid profile
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DOI：
10.1016/j.lab.2005.03.009
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发表时间：
2005-06-01
期刊：
影响因子：
--
通讯作者：
Arnett, DK
中科院分区：
文献类型：
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作者：
Tsai, MY;Hanson, NQ;Arnett, DK
尽管流感疫苗被广泛使用，但人们对其对炎症标志物测量的影响知之甚少。由于c反应蛋白（CRP）等炎症标志物越来越多地与血脂一起用于心血管疾病的临床评估和流行病学研究，我们评估了流感疫苗接种对炎症标志物和血浆脂质浓度的影响。我们在22名健康人接种流感疫苗前1至6小时以及接种疫苗后1、3和7天采血。测定血浆CRP、白细胞介素(IL)-6、单核细胞趋化蛋白1、肿瘤坏死因子α、IL-2可溶性受体α和血清淀粉样蛋白A，并比较第1、3和7天的平均绝对浓度和标准化值与平均基线值的差异。平均IL-6显著升高(P
Despite wide use of the influenza vaccine, relatively little is known about its effect on the measurement of inflammatory markers. Because inflammatory markers such as C-reactive protein (CRP) are increasingly being used in conjunction with lipids for the clinical assessment of cardiovascular disease and in epidemiologic studies, we evaluated the effect of influenza vaccination on markers of inflammation and plasma lipid concentrations. We drew blood from 22 healthy individuals I to 6 hours before they were given an influenza vaccination and 1, 3, and 7 days after the vaccination. Plasma CRP, interleukin (IL)-6, monocyte chemotactic protein 1, tumor necrosis factor alpha, IL-2 soluble receptor alpha, and serum amyloid A were measured, and differences in mean concentrations of absolute and normalized values on days 1, 3, and 7 were compared with mean baseline values. There was a significant increase in mean IL-6 (P