NEURAL DYSFUNCTION DURING HYPOGLYCEMIA
NEURAL DYSFUNCTION DURING HYPOGLYCEMIA
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DOI：
10.1136/adc.63.11.1353
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发表时间：
1988-11-01
影响因子：
5.2
通讯作者：
EYRE, JA
中科院分区：
文献类型：
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作者：
KOH, THHG;AYNSLEYGREEN, A;EYRE, JA
对于新生儿和儿童低血糖的定义及其在“无症状”时的意义存在争议。我们在17名儿童中测量了与血糖浓度相关的感觉诱发电位：13名禁食或给予胰岛素以研究内分泌或代谢异常，4名自发性低血糖发作。在血糖浓度低于2.6 mmol/l的11名儿童中，有10名记录到异常诱发电位;这20名儿童中有5名是“无症状”的。血糖浓度保持在2.6 mmol/l以上的6名儿童的诱发电位无变化。我们的研究结果表明，血糖浓度应保持在2.6 mmol/l以上，以确保正常的神经功能的儿童，无论是否存在异常的临床体征。
There is controversy over the definition of hypoglycaemia in neonates and children and over its significance when ''asymptomatic''. We measured sensory evoked potentials in relation to blood glucose concentration in 17 children: 13 were fasted or given insulin to investigate endocrine or metabolic abnormalities and four had spontaneous episodes of hypoglycaemia. Abnormal evoked potentials were recorded in 10 of the 11 children whose blood glucose concentration fell below 2.6 mmol/l; five of these 20 children were ''asymptomatic''. No change in evoked potentials was recorded in the six children whose blood glucose concentration remained above 2.6 mmol/l. Our findings suggest that the blood glucose concentration should be maintained above 2.6 mmol/l to ensure normal neural function in children irrespective of the presence or absence of abnormal clinical signs.