Hippocampal Neurogenesis in Conditions of Chronic Stress Induced by Sciatic Nerve Injury in the Rat
Hippocampal Neurogenesis in Conditions of Chronic Stress Induced by Sciatic Nerve Injury in the Rat
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DOI：
10.1159/000501236
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发表时间：
2019-09-01
影响因子：
2.7
通讯作者：
Manzhulo, Igor
中科院分区：
文献类型：
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作者：
Egorova, Evgeniia;Starinets, Anna;Manzhulo, Igor
海马齿状回是成人神经发生的主要部位，受到多种外部和内部因素的影响，包括周围胶质细胞的活动。本研究涉及大鼠坐骨神经损伤后海马神经发生的改变以及促炎性和神经保护性小胶质细胞/巨噬细胞活性的变化。在这里，我们证明，周围神经损伤引起的慢性疼痛在海马体中表现为增殖（PCNA +）和神经发生（DCX +）的减少，促炎细胞因子（CD86 +）的增加以及神经保护性（CD163 +）小胶质细胞/巨噬细胞的减少。我们认为小胶质细胞/巨噬细胞活性的病理性增加是慢性神经病理性疼痛中观察到的神经发生抑制的原因。
The dentate gyrus of the hippocampus is the primary location of adult neurogenesis, which is affected by a variety of external and internal factors, including activity of surrounding glial cells. This study concerns alterations in hippocampal neurogenesis and changes in activity of both proinflammatory and neuroprotective microglia/macrophages after sciatic nerve injury in the rat. Here, we demonstrated that the chronic pain induced by a peripheral nerve injury manifests in the hippocampus by a decrease in proliferation (PCNA+) and neurogenesis (DCX+), an increase in proinflammatory cytokines (CD86+), and a reduction in neuroprotective (CD163+) microglia/macrophages. We suggest that a pathological increase microglia/macrophage activity is the cause of neurogenesis suppression observed in chronic neuropathic pain.