HANTAAN VIRUS-INFECTION IN SUCKLING MICE - VIROLOGIC AND PATHOLOGIC CORRELATES
HANTAAN VIRUS-INFECTION IN SUCKLING MICE - VIROLOGIC AND PATHOLOGIC CORRELATES
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DOI：
10.1002/jmv.1890170203
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发表时间：
1985-01-01
影响因子：
12.7
通讯作者：
PETERS, CJ
中科院分区：
文献类型：
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作者：
MCKEE, KT;KIM, GR;PETERS, CJ
对汉坦病毒乳鼠模型进行了检查，以描绘器官水平感染的病毒学和组织病理学特征。在所有检查的器官中均检测到病毒抗原和感染性病毒，其中脑、肺和肾的滴度最高。在脑（弥漫性脑膜脑炎伴双侧对称丘脑坏死）、肝（胆周血管性肝炎）、肺（肺炎）和脾（淋巴增生）中发现了一系列组织学病变；这个四分体显然是这个模型系统所独有的。汉坦感染的新生小鼠的临床、病毒学、血清学和病理学发现的时间顺序表明疾病发病机制中存在免疫介导的机制。
The Hantaan virus suckling mouse model was examined to delineate virologic and histopathologic characteristics of infection at the organ level. Viral antigen and infectious virus were detected in all organs examined, with highest titers achieved in brain, lung, and kidney. A constellation of histologic lesions was identified in brain (diffuse meningoencephalitis with bilaterally symmetrical thalamic necrosis), liver (pericholangiohepatitis), lung (pneumonitis), and spleen (lymphoid hyperplasia); this tetrad is apparently unique to this model system. The chronology of clinical, virologic, serologic, and pathologic findings in Hantaan-infected newborn mice suggests an immune-mediated mechanism in disease pathogenesis.