Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
Immunohistochemical co-expression of carbonic anhydrase II with Kv1.4 and TRPV1 in rat small-diameter trigeminal ganglion neurons
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DOI：
10.1016/j.brainres.2005.02.082
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发表时间：
2005-05-24
期刊：
影响因子：
2.9
通讯作者：
Matsumoto, S
中科院分区：
文献类型：
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作者：
Tanimoto, T;Takeda, M;Matsumoto, S
采用免疫荧光法检测了碳酸酐酶II （CAII）与电压门控钾通道亚型1.4 （Kv1.4）或香草受体（TRPV1）在成年大鼠三叉神经节（TG）神经元中的共表达情况。小直径kv .1.4阳性TG神经元共表达CAII免疫反应性（47%）。大多数trpv1阳性的TG神经元（79%）具有CAII免疫反应性，但对神经丝蛋白（NF200）缺乏免疫反应性，NF200是具有髓鞘轴突的大TG神经元的制造物。cati -免疫活性TG神经元显示Kv 1.4和TRPV1的共同表达，这一事实使我们认为CAR可能是一种伤害性神经元标志物。(c) 2005 Elsevier B.V.版权所有
The co-expression of carbonic anhydrase II (CAII) with the voltage-gated potassium channel subtype 1.4 (Kv1.4) or the vanilloid receptor (TRPV1) was examined in adult rat trigeminal ganglion (TG) neurons by using the immunofluorescence method. The small-diameter Kv.1.4positive TG neurons co-expressed CAII immunoreactivity (47%). Most TRPV1-positive TG neurons (79%) had the CAII immunoreactivity, but showed a lack of immunoreactivity for a neurofilament protein (NF200), a maker of large TG neurons with myelinated axons. The fact that CATI-immumoreactive TG neurons revealed a common expression of both Kv 1.4 and TRPV1 leads us to suggest that CAR may be one of the nociceptive neuronal markers. (c) 2005 Elsevier B.V. All rights reserved.