SEASONAL INCIDENCE OF SOME CONGENITAL MALFORMATIONS IN THE CENTRAL NERVOUS SYSTEM IN SWEDEN, 1965–1972
SEASONAL INCIDENCE OF SOME CONGENITAL MALFORMATIONS IN THE CENTRAL NERVOUS SYSTEM IN SWEDEN, 1965–1972
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DOI：
10.1111/j.1651-2227.1977.tb07809.x
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发表时间：
1977-01
期刊：
影响因子：
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通讯作者：
B. Sandahl
中科院分区：
文献类型：
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作者：
B. Sandahl
摘要对瑞典1965 ~ 1972年出生婴儿先天性中枢神经系统畸形的季节变化趋势进行了调查。这项研究基于瑞典先天性畸形登记处的报告、国家卫生委员会的统计数据以及Malmö综合医院和隆德医院的记录。本研究分析的畸形包括无脑畸形、腹裂（伴或不伴脑积水）和孤立性脑积水。出生月份和最后一次月经（LMP）发生率的变化采用三种不同的方法进行统计检验：每个日历月记录的婴儿数量之间的异质性的标准χ2检验、爱德华兹方法和平方窦函数，所有方法都有或没有对每月出生出生率的变化进行校正。无脑畸形的LMP最大值出现在3月份，而腹裂的最大值出现在7月份。简要地讨论了可以解释这种季节性的因素。
Abstract Seasonal trends of some congenital CNS malformations in infants born in Sweden during the years 1965 to 1972 were investigated. The study is based on reports to the Swedish Register of Congenital Malformations, statistics from the National Board of Health, and records from Malmö General Hospital and the Hospital of Lund. The malformations analysed in this study are anencephaly, spina bifida aperta (with or without hydrocephalus) and isolated hydrocephalus. Variations in incidence of months of birth and last menstrual period (LMP) were tested statistically in three different ways: standard χ2‐test for heterogeneity between recorded numbers of infants each calender month, Edwards' method, and a squared sinus function, all with or without correction for variations in genera) monthly birth rates. Statistical significant seasonal variations were found for anencephaly with an LMP maximum in March and for spina bifida aperta with a maximum in July. Factors which can explain such seasonality are briefly discussed.