Pallambins A and B, Unprecedented Hexacyclic 19-nor-Secolabdane Diterpenoids from the Chinese Liverwort Pallavicinia ambigua
Pallambins A and B, Unprecedented Hexacyclic 19-nor-Secolabdane Diterpenoids from the Chinese Liverwort Pallavicinia ambigua
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Pallambins A 和 B，来自中国地钱的前所未有的六环 19-nor-Secolabdane 二萜
DOI：
10.1021/ol3000124
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发表时间：
2012-02-17
期刊：
影响因子：
5.2
通讯作者：
Lou, Hong-Xiang
中科院分区：
文献类型：
--
作者：
Wang, Li-Ning;Zhang, Jiao-Zhen;Lou, Hong-Xiang
Pallambins A(1)和B(2)，两种具有前所未有的四环的新型19-no -7,8-二萜[4.4.0(3,5)]。从中国苔类植物Pallavicinia ambigua中分离到10烷骨架（0(2,8)）和一对结构相关的异构体pallambin C(3)和D(4)。通过核磁共振、x射线衍射和CD分析确定了它们的绝对构型。还测试了它们对人类癌细胞的初步细胞毒性。
Pallambins A (1) and B (2), two novel 19-nor-7,8-secolabdane diterpenoids with unprecedented tetracyclo[4.4.0(3,5).0(2,8)]decane skeletons, along with a pair of structurally related isomers, pallambins C (3) and D (4), were isolated from the Chinese liverwort Pallavicinia ambigua. Their structures with absolute configurations were determined by means of NMR, X-ray diffraction, and CD analyses. Their preliminary cytotoxicity to human cancer cells was also tested.