Brain temperature remains stable during the day: a study of diffusion-weighted imaging thermometry in healthy individuals
Brain temperature remains stable during the day: a study of diffusion-weighted imaging thermometry in healthy individuals
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DOI：
10.1007/s00234-023-03142-9
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发表时间：
2023-03-23
期刊：
影响因子：
2.8
通讯作者：
Miki，Yukio
中科院分区：
文献类型：
--
作者：
Horiuchi，Daisuke;Shimono，Taro;Miki，Yukio
目的利用磁共振（MR）弥散加权成像（DWI）测温技术研究健康人脑温度的日常波动，阐明脑、体温和性别之间的关系。方法于2021年7月至2022年1月招募32名年龄匹配的健康男女志愿者（男性= 16岁，20-38岁）。在同一天的早晚阶段分别进行脑MR检查，用DWI测温法计算脑温度。在每次磁共振检查中也测量体温。使用成对检验对两个阶段之间的身体和大脑温度进行组间比较。以性别、夜间脑温度、性别与夜间脑温度的交互作用为协变量，采用多元线性回归模型预测晨起脑温度。结果所有受试者、男性组和女性组的夜间体温均显著高于早晨（p< 0.001, = 0001, < 0.001）。同时，在每次分析中，早上和晚上的大脑温度没有显著差异（p分别= 0.23、0.70和0.16）。多元线性回归分析显示，早晨脑温度与性别显著相关（p= 0.038），晚上脑温度显著相关（p< 0.001），性别与晚上脑温度的交互作用显著（p= 0.036）。结论与体温不同，脑温度无明显的日波动；然而，大脑温度的每日波动可能因性别而异。
PurposeTo investigate the daily fluctuations in brain temperature in healthy individuals using magnetic resonance (MR) diffusion-weighted imaging (DWI) thermometry and to clarify the associations between the brain and body temperatures and sex.MethodsThirty-two age-matched healthy male and female volunteers (male = 16, 20–38 years) were recruited between July 2021 and January 2022. Brain MR examinations were performed in the morning and evening phases on the same day to calculate the brain temperatures using DWI thermometry. Body temperature was also measured in each MR examination. Group comparisons of body and brain temperatures between the two phases were performed using pairedt-tests. A multiple linear regression model was used to predict the morning brain temperature using sex, evening brain temperature, and the interaction between sex and evening brain temperature as covariates.ResultsBody temperatures were significantly higher in the evening than in the morning in all participants, male group, and female group (p< 0.001, = 0001, and < 0.001, respectively). Meanwhile, no significant difference was observed between the morning and evening brain temperatures in each analysis (p= 0.23, 0.70, and 0.16, respectively). Multiple linear regression analysis showed significant associations of morning brain temperature with sex (p= 0.038), evening brain temperature (p< 0.001), and the interaction between sex and evening brain temperature (p= 0.036).ConclusionUnlike body temperature, brain temperature showed no significant daily fluctuations; however, daily fluctuations in brain temperature may vary depending on sex.