Dynamic Ca(2+) signal modalities in the vascular endothelium.
Dynamic Ca(2+) signal modalities in the vascular endothelium.
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DOI：
10.1111/j.1549-8719.2012.00180.x
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Solodushko V
中科院分区：
文献类型：
--
作者：
Taylor MS;Francis M;Qian X;Solodushko V
内皮对于正常的血管调节至关重要。尽管与广泛的内皮 Ca2+ 升高相关的急性血管舒张是众所周知的，但内皮细胞中 Ca2+ 依赖性信号的控制和靶向却知之甚少。最近的研究表明，沿着内膜基底发生的局部 IP3 驱动的 Ca2+ 事件可能为各种内皮影响提供基础基础。在这里，我们概述了动态内皮 Ca2+ 信号，并讨论了这些信号在动脉张力的恒定内皮控制和体内功能反应滴定中的潜在作用。特别是，我们专注于对这些信号的特性和最终影响做出贡献的功能结构，并探索评估其在完整组织中的普遍性和特定模式的新途径。最后，我们讨论通过修改这些固有信号来招募空间和时间效应器。有人认为，内皮 Ca2+ 信号传导是一个连续体，其中沿着内皮的储存释放成分和细胞靶标的特定框架允许不同的 Ca2+ 信号扩展模式和独特的效应器募集特征。这些固有成分的精确组成和分布可能是动态内皮控制和不同血管床特殊功能的基础。
The endothelium is vital to normal vasoregulation. Although acute vasodilation associated with broad endothelial Ca2+ elevation is well-known, the control and targeting of Ca2+ dependent signals in the endothelium is poorly understood. Recent studies have revealed localized IP3-motivated Ca2+ events occurring basally along the intima that may provide the fundamental basis for various endothelial influences. Here, we provide an overview of dynamic endothelial Ca2+ signals and discuss the potential role of these signals in constant endothelial control of arterial tone and the titration of functional responses in vivo. In particular, we focus on the functional architecture contributing to the properties and ultimate impact of these signals and explore new avenues in evaluating their prevalence and specific modalities in intact tissue. Finally, we discuss spatial and temporal effector recruitment through modification of these inherent signals. It is suggested that endothelial Ca2+ signaling is a continuum in which the specific framework of store-release components and cellular targets along the endothelium allows for differential modes of Ca2+ signal expansion and distinctive profiles of effector recruitment. The precise composition and distribution of these inherent components may underlie dynamic endothelial control and specialized functions of different vascular beds.
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