Novel ESCRT functions in cell biology: spiraling out of control?
Novel ESCRT functions in cell biology: spiraling out of control?
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DOI：
10.1016/j.ceb.2016.03.008
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发表时间：
2016-08-01
影响因子：
7.5
通讯作者：
Stenmark, Harald
中科院分区：
文献类型：
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作者：
Campsteijn, Coen;Vietri, Marina;Stenmark, Harald
转运所需的内体分选复合物（ESCRT），最初确定其在内体蛋白分选和多泡内体（MVEs）的生物发生中的作用，已被证明是一种多功能的机制，用于对充满胞质溶胶的狭窄膜内陷进行退化和断裂。早期描述的ESCRT机制的功能是包膜病毒的出芽和细胞动力学终止，最近出现了一些新的ESCRT功能。这些包括细胞动力学解离检查点控制、质膜修复、外囊泡释放、核孔复合物的质量控制、神经元修剪和新形成的核包膜的密封。在这里，我们回顾这些新的ESCRT机制，并讨论各种ESCRT依赖的活动之间的相似性和差异。
The endosomal sorting complex required for transport (ESCRT), originally identified for its role in endosomal protein sorting and biogenesis of multivesicular endosomes (MVEs), has proven to be a versatile machinery for involution and scission of narrow membrane invaginations filled with cytosol. Budding of enveloped viruses and cytokinetic abscission were early described functions for the ESCRT machinery, and recently a number of new ESCRT functions have emerged. These include cytokinetic abscission checkpoint control, plasma membrane repair, exovesicle release, quality control of nuclear pore complexes, neuron pruning, and sealing of the newly formed nuclear envelope. Here we review these novel ESCRT mechanisms and discuss similarities and differences between the various ESCRT-dependent activities.