Classical oncogenes and tumor suppressor genes: A comparative genomics perspective
Classical oncogenes and tumor suppressor genes: A comparative genomics perspective
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DOI：
10.1038/sj.neo.7900090
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发表时间：
2000-05-01
期刊：
影响因子：
4.8
通讯作者：
Zhang, J
中科院分区：
文献类型：
--
作者：
Pickeral, OK;Li, JZ;Zhang, J
我们整理了癌症相关基因的参考集，并根据首次克隆以来获得的分子信息和资源重新分析了它们的序列，对人类致癌基因和肿瘤抑制基因进行了同源性研究，与线虫、秀丽隐杆线虫的完整蛋白质组、小鼠和大鼠以及果蝇、果蝇的部分蛋白质组进行了比较。我们的结果表明，用于识别不同生物体中假定的功能等效基因产物的简单、半自动化生物信息学方法可能常常会产生误导。本文 (1) 的电子补充提供了我们的比较基因组学分析以及绘图数据、物理 cDNA 资源以及已发表文献和评论的链接的综合视图，从而为癌症生物学创建了了解人类和其他生物体基因组的“窗口”。
We have curated a reference set of cancer-related genes and reanalyzed their sequences in the light of molecular information and resources that have become available since they were first cloned, Homology studies were carried out for human oncogenes and tumor suppressors, compared with the complete proteome of the nematode, Caenorhabditis elegans, and partial proteomes of mouse and rat and the fruit fly, Drosophila melanogaster. Our results demonstrate that simple, semi-automated bioinformatics approaches to identifying putative functionally equivalent gene products in different organisms may often be misleading. An electronic supplement to this article(1) provides an Integrated view of our comparative genomics analysis as well as mapping data, physical cDNA resources and links to published literature and reviews, thus creating a "window" into the genomes of humans and other organisms for cancer biology.