Sequentially annealed highly cross-linked polyethylene reduced in vivo wear particle generation in total knee arthroplasty
Sequentially annealed highly cross-linked polyethylene reduced in vivo wear particle generation in total knee arthroplasty
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DOI：
10.1177/2309499017718909
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发表时间：
2017-07-06
影响因子：
1.6
通讯作者：
Nakamura, Hiroaki
中科院分区：
文献类型：
--
作者：
Minoda, Yukihide;Hata, Kanako;Nakamura, Hiroaki
介绍：最近引入了顺序退火高交联聚乙烯（HXLPE）以减少全膝关节置换术（TKA）中的磨损。然而，连续退火HXLPE在磨粒生成方面的体内优势仍存在争议。本研究旨在比较TKA后顺序退火HXLPE和传统聚乙烯之间的体内磨损颗粒特征。材料与方法：术后12个月，从8个采用连续退火HXLPE的膝关节和8个采用传统聚乙烯的膝关节中采集滑液。分离聚乙烯颗粒，并使用扫描电子显微镜和图像分析仪进行检查。结果如下：每个膝关节中的磨损颗粒总数为2.1 +/- 1.0 x 10（7），采用顺序退火HXLPE（平均值+/-标准差），4.9 +/- 3.6 x 10（7），采用传统聚乙烯（p = 0.036）。粒度（等效圆直径）为1.01 +/- 0.26 μ m，采用顺序退火HXLPE，1.02 +/- 0.20 μ m，采用传统聚乙烯（p = 0.674）。连续退火HXLPE的纵横比为1.33 +/- 0.04，传统聚乙烯为1.39 +/- 0.10（p = 0.462）。结论：与常规聚乙烯相比，顺序退火的HXLPE使体内聚乙烯磨损颗粒减少了58%，而颗粒尺寸和形状没有显著变化。
Introduction: Sequentially annealed highly cross-linked polyethylene (HXLPE) was recently introduced to reduce the wear in total knee arthroplasty (TKA). However, an in vivo advantage of sequentially annealed HXLPE on wear particle generation is still controversial. The purpose of this study is to compare the characteristics of in vivo wear particles between sequentially annealed HXLPE and conventional polyethylene after TKA. Materials and Methods: Synovial fluid was obtained from the eight knees with sequentially annealed HXLPE and from eight knees with conventional polyethylene 12 months after the operation. Polyethylene particles were isolated and examined using a scanning electron microscope and image analyzer. Results: Total number of wear particles in each knee was 2.1 +/- 1.0 x 10(7) with sequentially annealed HXLPE (mean +/- standard deviation) and 4.9 +/- 3.6 x 10(7) with conventional polyethylene (p = 0.036). Particle size (equivalent circle diameter) was 1.01 +/- 0.26 mu m with sequentially annealed HXLPE and 1.02 +/- 0.20 m with conventional polyethylene (p = 0.674). Aspect ratio was 1.33 +/- 0.04 with sequentially annealed HXLPE and 1.39 +/- 0.10 with conventional polyethylene (p = 0.462). Conclusions: The sequentially annealed HXLPE reduced the in vivo polyethylene wear particles by 58% compared with conventional polyethylene without the significant change of particle size and shape.