High-Density Lipoprotein Function and Dysfunction in Health and Disease
High-Density Lipoprotein Function and Dysfunction in Health and Disease
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DOI：
10.1007/s10557-018-06846-w
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发表时间：
2019-04-01
影响因子：
3.4
通讯作者：
Charakida, Marietta
中科院分区：
文献类型：
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作者：
Chiesa, Scott T.;Charakida, Marietta
高密度脂蛋白胆固醇（HDL-c）长期以来被认为是“好胆固醇”，因为它与未来心血管疾病的风险呈明显的负相关。然而，最近的研究对HDL-c在这一关系中的因果作用提出了质疑，因为遗传学研究和大量大规模随机对照试验都没有发现HDL-c水平升高对心血管有保护作用的证据。相反，焦点已经转移到HDL粒子的功能特性上。有证据表明，在炎症环境下，HDL的组成和功能都可能发生显著改变，使其从具有血管保护作用的抗动脉粥样硬化颗粒转变为有害的促动脉粥样硬化当量。本文将总结HDL与CVD风险相关的证据，探讨慢性炎症性疾病中可能发生的HDL组成和功能变化的最新证据，并讨论未来HDL修饰治疗干预措施的潜力。
High-density lipoprotein cholesterol (HDL-c) has long been referred to as good cholesterol' due to its apparent inverse relationship with future CVD risk. More recent research has questioned a causal role for HDL-c in this relationship, however, as both genetic studies and numerous large-scale randomised controlled trials havefound no evidence of a cardiovascular protective effect when HDL-c levels are raised. Instead, focus has switched to the functional properties of the HDL particle. Evidence suggests that both the composition and function of HDL may be significantly altered in the context of an inflammatory milieu, transforming the particle from a vasoprotective anti-atherogenic particle to a noxious pro-atherogenic equivalent. This review will summarise evidence relating HDL to CVD risk, explore recent evidence characterising changes in the composition and function of HDL that may occur in chronic inflammatory diseases, and discuss the potential for future HDL-modifying therapeutic interventions.