Tim-3: an activation marker and activation limiter of innate immune cells.
Tim-3: an activation marker and activation limiter of innate immune cells.
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Tim-3：先天免疫细胞的激活标记和激活限制剂。
DOI：
10.3389/fimmu.2013.00449
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发表时间：
2013-12-10
影响因子：
7.3
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Han G;Chen G;Shen B;Li Y
Tim-3最初在活化的Th 1、Th 17和Tc 1细胞上鉴定，并在与其配体Gal-9结合后诱导T细胞死亡或耗竭。观察到T细胞上Tim-3表达失调与许多临床疾病进展之间的关系，已确定该分子是干预获得性免疫的重要靶点。最近的数据表明，它还在调节巨噬细胞、单核细胞、树突状细胞、肥大细胞、自然杀伤细胞和内皮细胞的活性中起关键作用。尽管潜在的机制仍不清楚，但这些先天免疫细胞上Tim-3表达的失调导致过度或抑制的炎症反应和随后的自身免疫损伤或病毒或肿瘤逃避。在这篇综述中，我们专注于Tim-3在先天免疫细胞上的表达和功能，并讨论（1）Tim-3如何在不同的先天免疫细胞上表达和调节;（2）它如何影响不同的先天免疫细胞的活性;（3）先天免疫细胞上的Tim-3表达失调如何影响获得性免疫和疾病进展。Tim-3通过其不同的表达参与先天免疫细胞的最佳激活。更好地理解Tim-3通路在先天免疫中的生理病理学作用将为临床疾病（如自身免疫性疾病、慢性病毒感染和癌症）的发病机制提供新的线索，并提出新的干预方法。
Tim-3 was initially identified on activated Th1, Th17, and Tc1 cells and induces T cell death or exhaustion after binding to its ligand, Gal-9. The observed relationship between dysregulated Tim-3 expression on T cells and the progression of many clinical diseases has identified this molecule as an important target for intervention in adaptive immunity. Recent data have shown that it also plays critical roles in regulating the activities of macrophages, monocytes, dendritic cells, mast cells, natural killer cells, and endothelial cells. Although the underlying mechanisms remain unclear, dysregulation of Tim-3 expression on these innate immune cells leads to an excessive or inhibited inflammatory response and subsequent autoimmune damage or viral or tumor evasion. In this review, we focus on the expression and function of Tim-3 on innate immune cells and discuss (1) how Tim-3 is expressed and regulated on different innate immune cells; (2) how it affects the activity of different innate immune cells; and (3) how dysregulated Tim-3 expression on innate immune cells affects adaptive immunity and disease progression. Tim-3 is involved in the optimal activation of innate immune cells through its varied expression. A better understanding of the physiopathological role of the Tim-3 pathway in innate immunity will shed new light on the pathogenesis of clinical diseases, such as autoimmune diseases, chronic viral infections, and cancer, and suggest new approaches to intervention.