Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
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DOI：
10.1038/nm0298-215
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发表时间：
1998-02-01
期刊：
影响因子：
82.9
通讯作者：
Debré, P
中科院分区：
文献类型：
--
作者：
Gorochov, G;Neumann, AU;Debré, P
通过分析HIV-1感染过程中和联合抗逆转录病毒治疗后β链CDR 3高变区的不同长度，对T细胞抗原受体（TCR）库进行了纵向研究。CD 8（+）T细胞库的使用在自然进展的所有阶段都受到严重限制，并在治疗的前六个月持续存在。相反，在感染的早期阶段没有发现显著的CD 4（+）T细胞谱紊乱，但与艾滋病的进展有关。在10例出现治疗前紊乱的患者中，8例良好应答者观察到CD 4（+）库正常化，但2例治疗不成功的患者未观察到。这些结果表明，除了CD 4（+）细胞计数上升，有效控制HIV复制可能允许CD 4（+）库平衡的定性修改。
The T-cell antigen receptor (TCR) repertoire was studied longitudinally by analyzing the varying lengths of the beta chain CDR3 hypervariable region during the course of HIV-1 infection and following combination antiretroviral therapy. Drastic restrictions in CD8(+) T-cell repertoire usage were found at all stages of natural progression and persisted during the first six months of treatment. In contrast, significant CD4(+) T-cell repertoire perturbations were not found in early stages of infection but correlated with progression to AIDS. Out of ten patients presenting with pretreatment perturbations, normalization of the CD4(+) repertoire was observed in eight good responders, but not in two cases of unsuccessful therapy. These results indicate that, besides CD4(+) cell count rise, an efficient control of HIV replication may allow qualitative modifications of the CD4(+) repertoire balance.