REDUCED DEPOSITION OF COLLAGEN IN THE DEGENERATED ARTICULAR-CARTILAGE OF DOGS WITH DEGENERATIVE JOINT DISEASE
REDUCED DEPOSITION OF COLLAGEN IN THE DEGENERATED ARTICULAR-CARTILAGE OF DOGS WITH DEGENERATIVE JOINT DISEASE
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DOI：
10.1016/0304-4165(82)90011-3
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
LUST, G
中科院分区：
文献类型：
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作者：
BURTONWURSTER, N;HUICHOU, CS;LUST, G
Collagen metabolism in the focal degenerated cartilage from immature dogs with degenerative joint disease was compared with that in the adjacent normal cartilage of the same joint surface. The deposition of collagen into the cartilage in vitro as measured by accumulation of hydroxy[14C]proline was decreased in the early and in advanced stages of cartilage degeneration. The deposition of collagen into cartilage in vivo, as measured by the accumulation of hydroxy[3H]proline (i.v. injected [3H]proline), also was reduced in the degenerated cartilages of a dog with degenerative joint disease. Gel electrophoretic analysis revealed that degenerated cartilage contained less .alpha.1 II collagen chains but increased amounts of larger proteins. Degenerated cartilage contained more water, increased amounts of unidentified non-collagenous protein, increased collagenolytic enzyme activity and fewer chondrocytes. Decreased deposition of collagen would result in collagen depletion in the foci of degenerated cartilage in joints of dogs with degenerative joint disease.
