The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis.
The prognostic value of cytotoxic T-lymphocyte antigen 4 in cancers: a systematic review and meta-analysis.
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细胞毒性 T 淋巴细胞抗原 4 在癌症中的预后价值：系统评价和荟萃分析
DOI：
10.1038/srep42913
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发表时间：
2017-02-17
影响因子：
4.6
通讯作者：
Zhang J
中科院分区：
文献类型：
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作者：
Hu P;Liu Q;Deng G;Zhang J;Liang N;Xie J;Zhang J
分析CTLA-4在癌症中的预后作用的研究结果是有争议的。因此，我们的荟萃分析的目的是澄清CTLA-4表达和OS之间的相关性在不同的癌症病例。使用PubMed、EMBASE、Web of Science和科克伦图书馆检索相关文献。收集这些研究的临床病理特征、风险比（HR）和95%置信区间（CI），并使用Stata 12.0版软件进行分析。合并HR值显示CTLA-4表达水平与肿瘤相关OS之间无显著相关性（HR：1.24，95% CI：0.98-1.56，I2 = 71.7%，P = 0.000）。进行进一步的亚组分析，并根据实验方法、CTLA-4来源和癌症类型进行分类。调查显示，在SNP亚组中CTLA-4高表达与OS之间存在显著相关性（HR：1.47，95%CI：1.14-1.89），并且通过PCR（HR：1.50，95%CI：1.20-1.86）和流式细胞术（HR：2.76，95%CI：1.49-5.14）分析亚组。此外，我们的分析观察到患者和对照组之间在inCTLA-4+ CD 4+淋巴细胞、surCTLA-4+ CD 4+淋巴细胞、inCTLA-4+ CD 8+淋巴细胞和surCTLA-4+ CD 8+淋巴细胞方面存在显著差异。CTLA-4的作用的知识可能被用于有效地指导癌症患者的适当预后和治疗策略。
The outcomes of studies analyzing the prognostic role of CTLA-4 in cancers are controversial. Therefore, the aim of our meta-analysis was to clarify the correlation between CTLA-4 expression and OS in different cancer cases. Relevant literature was searched using PubMed, EMBASE, Web of Science, and the Cochrane Library. The clinicopathological features, hazard ratio (HR) and 95% confidence intervals (CI) were collected from these studies and were analyzed using Stata version 12.0 software. The pooled HR values showed no significant correlation between CTLA-4 expression levels and OS in relation to tumors (HR: 1.24, 95% CI: 0.98–1.56, I2 = 71.7%, P = 0.000). Further subgroup analyses were conducted and categorized by experimental methods, CTLA-4 sources and cancer types. The survey showed a significant correlation (HR: 1.47, 95% CI: 1.14–1.89) between high expression of CTLA-4 and OS in the SNP subgroup, and subgroups analyzing by PCR (HR: 1.50, 95% CI: 1.20–1.86) and flow cytometry (HR: 2.76, 95% CI: 1.49–5.14). In addition, our analysis observed significant differences between patients and controls in inCTLA-4+CD4+ lymphocytes, surCTLA-4+CD4+ lymphocytes, inCTLA-4+CD8+ lymphocytes, and surCTLA-4+CD8+ lymphocytes. Knowledge of the effects of CTLA-4 could potentially be used to effectively guide appropriate prognosis and therapeutic strategies in cancer patients.
影响因子：
3.7
作者：
Wang E;Zhao Y;Monaco A;Uccellini L;Kirkwood JM;Spyropoulou-Vlachou M;Panelli MC;Marincola FM;Gogas H
通讯作者：
Gogas H