The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum
The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum
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DOI：
10.1016/j.bmc.2007.04.036
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发表时间：
2007-07-15
影响因子：
3.5
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Liu, Jie;Shimizu, Kuniyoshi;Kondo, Ryuichiro
灵芝子实体的乙醇提取物的抗雄激素活性先前已被报道。灵芝醇B具有5 α-还原酶抑制活性和结合雄激素受体（AR）的能力，可抑制雄激素诱导的LNCaP细胞生长，并抑制由睾酮诱导的大鼠腹侧前列腺再生。灵芝醇B对AR信号的下调是其抗雄激素活性的重要机制。鉴于PSA（前列腺特异性抗原，一种公认的前列腺癌预后指标）下调的事实，本研究的一个重要意义是，旨在降低雄激素信号传导幅度的灵芝酚B干预策略可能有助于控制前列腺癌的发病率。因此，我们的研究结果表明，灵芝醇B可能是通过抑制雄激素及其受体的功能，在前列腺癌和良性前列腺增生（BPH）的治疗有用。(c)2007爱思唯尔有限公司版权所有。
The anti-androgenic activity of the ethanol extract of the fruiting body of Ganoderma lucidum has been previously reported. Ganoderol B with 5 alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor. (c) 2007 Elsevier Ltd. All rights reserved.