Associations of birth size, gestational age, and adult size with intellectual performance: Evidence from a cohort of Norwegian men
Associations of birth size, gestational age, and adult size with intellectual performance: Evidence from a cohort of Norwegian men
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DOI：
10.1203/pdr.0b013e31815586e9
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发表时间：
2007-11-01
影响因子：
3.6
通讯作者：
Bjerkedal, Tor
中科院分区：
文献类型：
--
作者：
Eide, Martha G.;Oyen, Nina;Bjerkedal, Tor
产前和产后生长发育对智力表现的影响尚不清楚。我们研究了出生大小和胎龄与智力表现的关系，并探讨了这些关系是否受到成年体型和社会因素的影响。在这项全国性的队列研究中，在挪威医学出生登记处（1967-1979年）登记的317 761名男婴的记录与挪威征兵服务（1984-1999年）有关。使用绝对值和标准化（z评分）值评估18岁时由于出生体重和出生身长导致的智力测试评分变化。平均智力得分随胎龄、出生体重和出生身长的增加而增加。然而，观察到胎龄> 41周和出生体重> 4500 g的智力表现下降。出生大小与胎龄对智力的影响有很强的交互作用（p < 0.0005）。根据成年人的体型进行调整后，出生时的体型与智力表现之间的关联大大减弱。由出生尺寸解释的智力表现的总体R-2 < 1%;然而，将成年体型和社会因素添加到模型中将R-2增加到12%。总之，出生大小与智力表现的关联很弱，但在调整成年体型和社会因素后仍然存在。
The influences of prenatal and postnatal growth on intellectual performance are unclear. We examined the associations of birth size and gestational age with intellectual performance and explored whether these associations were influenced by adult body size and social factors. In this nationwide cohort study, the records of 317,761 male infants registered in the Medical Birth Registry of Norway (1967-1979) were linked to the Norwegian Conscript Service (1984-1999). The variation in intelligence test score at age 18 due to birth weight and birth length was evaluated using absolute and standardized (z scores) values. Mean intelligence score increased by gestational age, birth weight, and birth length. However, a decline in intellectual performance was observed for gestational age > 41 wk and birth weight > 4500 g. There was a strong interaction on intellectual performance between birth size and gestational age (p < 0.0005). Adjusting for adult size strongly attenuated the association of birth size with intellectual performance. The overall R-2 of intellectual performance explained by birth size was < 1%; however, adding adult body size and social factors to the model increased R-2 to 12%. In conclusion, the association of birth size with intellectual performance was weak, but still present after adjustment for adult body size and social factors.