Complex dynamics and stability of resistance to antimalarial drugs
Complex dynamics and stability of resistance to antimalarial drugs
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DOI：
10.1017/s0031182005009790
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发表时间：
2006-05-01
期刊：
影响因子：
2.4
通讯作者：
Hastings, I. M.
中科院分区：
文献类型：
--
作者：
Hastings, I. M.
一系列抗疟疾药物已被用于治疗人类恶性疟疾，但每一种药物都因抗药性的传播而无效。人们的共识一直是，一旦出现，阻力将不可避免地迅速增加到100%。然而，最近的实地证据表明，这不是不可避免的，耐药性最初可能会传播，然后稳定在相对较低的频率。有人提出，共同感染同一个人的不同疟疾克隆之间的激烈竞争可以产生复杂的动态，能够解释这一观察。标准种群遗传分析证实了这一说法。因此，抗疟药耐药性演变的动力学可能比以前认识到的要复杂得多，可以解决实地数据与耐药性演变的基本理论之间的明显矛盾。这种解释是新颖的，其结果同样适用于其他寄生虫种，其中同一宿主的多次感染是常见的。
A succession of antimalarial drugs has been deployed to treat human falciparum malaria but each has, in turn, been nullified by the spread of drug resistance. The consensus view has always been that, once present, resistance will inevitably rapidly increase to 100%. However, recent field evidence has shown this is not inevitable, and that drug resistance may initially spread and then stabilize at relatively low frequencies. It is proposed that intense competition between separate malaria clones co-infecting the same human can generate complex dynamics capable of explaining this observation. Standard Population genetic analysis confirms this assertion. The dynamics underlying the evolution of antimalarial resistance may therefore be much more complex than previously realized, and can resolve the apparent paradox between field data and the underlying theory of the evolution of resistance. This explanation is novel and the results are equally applicable to other parasitic species where multiple infections of the same host are common.