The daidzein- and estradiol- induced anorectic action in CCK or leptin receptor deficiency rats
The daidzein- and estradiol- induced anorectic action in CCK or leptin receptor deficiency rats
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DOI：
10.1080/09168451.2015.1018123
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发表时间：
2015-07-03
影响因子：
1.6
通讯作者：
Kishida, Taro
中科院分区：
文献类型：
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作者：
Fujitani, Mina;Mizushige, Takafumi;Kishida, Taro
本实验观察了大豆苷元喂养和雌二醇处理对CCK1R缺陷大鼠、ObRb缺陷大鼠及其野生型大鼠摄食量的影响。这些大鼠接受了卵巢切除或假手术。在5周的实验中，每只大鼠分为三组：对照组、大豆苷元(150 mg/kg饲料)组和雌二醇组(4.2 mg/只/只/天)。在CCK1R+和CCK1R-大鼠中，大豆苷元喂养和雌二醇处理都显著减少了摄食量。喂饲大豆苷元显著减少了去卵巢的ObRb大鼠的摄食量，但对ObRb+大鼠没有影响。雌激素治疗可显著降低去卵巢大鼠的摄食量。在去卵巢大鼠中，雌二醇处理显著增加子宫重量，而大豆苷元喂养不改变子宫重量，这表明在我们的实验中，大豆苷元可能没有或很弱的雌激素样作用。这些结果表明，CCK1R和ObRb信号在大豆苷元和雌二醇诱导的厌食作用中不是必需的。
We investigated the effect of daidzein feeding and estradiol treatment on food intake in cholecystokinin-1 receptor (CCK1R) deficiency, leptin receptor (ObRb) deficiency rats and their wild-type rats. These rats underwent an ovariectomy or a sham operation. For the 5 week experiment, each rat was divided in three groups: control, daidzein (150mg/kg diet), and estradiol (4.2 mu g/rat/day) groups. In both CCK1R+ and CCK1R- rats, daidzein feeding and estradiol treatment significantly decreased food intake. Daidzein feeding significantly reduced food intake in ovariectomized ObRb- rats, although not in ObRb+ rats. Estradiol treatment significantly lowered food intake in ovariectomized ObRb+ and ObRb- rats. In the ovariectomized rats, estradiol treatment significantly increases uterine weight, while daidzein feeding did not change it, suggesting that daidzein might have no or weak estrogenic effect in our experiment. These results suggest that CCK1R and ObRb signalings were not essential for the daidzein- and estradiol-induced anorectic action.