Inflammation associated with the postprandial lipolysis of triglyceriderich lipoproteins by lipoprotein lipase
Inflammation associated with the postprandial lipolysis of triglyceriderich lipoproteins by lipoprotein lipase
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DOI：
10.1007/s11883-009-0031-9
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发表时间：
2009-05-01
影响因子：
5.8
通讯作者：
Rutledge, John C.
中科院分区：
文献类型：
--
作者：
Higgins, Laura J.;Rutledge, John C.
尽管高甘油三酯血症一再被认为是一种致动脉粥样硬化性疾病，但关于脂蛋白脂肪酶从富含甘油三酯的脂蛋白中释放的产物的致动脉粥样硬化性，存在相互矛盾的报道。甘油三酯的水解是乳糜微粒和极低密度脂蛋白被代谢并从循环中清除的正常过程，这表明脂蛋白脂肪酶在降低甘油三酯的循环水平方面具有有益作用，因此，降低了动脉粥样硬化负荷。然而，许多体外研究表明，脂肪分解产物如脂肪酸诱导血管细胞炎症，这可以引发或加剧动脉粥样硬化。本文综述了脂蛋白脂酶对血管炎症影响的最新研究结果和意义，扩大了人类餐后研究，动物模型和体外实验模型之间存在的争议。
Although hypertriglyceridemia has repeatedly been implicated as an atherogenic condition, there are conflicting reports concerning the atherogenicity of products released from triglyceride-rich lipoproteins by lipoprotein lipase. The hydrolysis of triglyceride is a normal process by which chylomicrons and very low-density lipoproteins are metabolized and cleared from the circulation, which would suggest a beneficial role for lipoprotein lipase in reducing circulating levels of triglyceride and, therefore, reducing atherosclerotic burden. However, many in vitro studies have shown that lipolysis products such as fatty acids induce vascular cell inflammation, which can initiate or exacerbate atherosclerosis. This review summarizes the results and implications of recent studies on the effects of lipoprotein lipase on vascular inflammation, expanding upon existing controversy among human postprandial studies, animal models, and in vitro experimental models.