Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study
Effects of Asian dust on daily cough occurrence in patients with chronic cough: A panel study
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DOI：
10.1016/j.atmosenv.2014.04.034
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发表时间：
2014-08-01
影响因子：
5
通讯作者：
Nakamura, Hiroyuki
中科院分区：
文献类型：
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作者：
Higashi, Tomomi;Kambayashi, Yasuhiro;Nakamura, Hiroyuki
亚洲粉尘，在日语中被称为kosa，是一个主要的公共卫生问题。在这项小组研究中，我们评估了暴露于科沙对每日咳嗽发生的影响。研究对象为2011年1月至2011年6月在金泽大学医院接受哮喘、咳嗽变异性哮喘或特应性咳嗽治疗的86例患者。通过光探测和测距（LIDAR）测量获得科沙和球形颗粒的日平均浓度，并将其分为1级（0 μ g/m(3)）到5级（超过100 μ g/m(3)）。采用logistic回归方法，用广义估计方程分析高斯沙与咳嗽的关系。科沙对咳嗽的作用在所有等级都有潜在的时滞效应。特别是在滞后0（暴露日），观察到剂量反应关系：参照物（1级）以上的2、3、4和5级的比值比分别为1.111（95%可信区间（CI）： 0.995-1.239）、1.171 （95% CI: 1.006 -1.363）、1.357 （95% CI: 1.029-1.788）和1.414 （95% CI: 0.983-2.036）。在无哮喘的患者中，相关性更高：2级、3级、4级和5级的比值比分别为1.223 （95% CI: 0.999-1.497）、1309 （95% CI: 0.987-1.737）、1.738 （95% CI: 1.029-2.935）和2.403 （95% CI: 1.158-4.985）。在调整球形颗粒或空气动力学直径小于2.5 μ m的颗粒物（PM2.5）的浓度后，这些关联仍然存在。我们的研究结果表明，咳嗽是一个环境因素，在剂量反应关系中诱发咳嗽。(C) 2014 Elsevier Ltd.版权所有。
Asian dust, known as kosa in Japanese, is a major public health concern. In this panel study, we evaluated the effects of exposure to kosa on daily cough occurrence. The study subjects were 86 patients being treated for asthma, cough variant asthma, or atopic cough in Kanazawa University Hospital from January 2011 to June 2011. Daily mean concentrations of kosa and spherical particles were obtained from light detection and ranging (LIDAR) measurements, and were categorized from Grade 1 (0 mu g/m(3)) to 5 (over 100 mu g/m(3)). The association between kosa and cough was analyzed by logistic regression with a generalized estimating equation. Kosa effects on cough were seen for all Grades with potential time lag effect. Particularly at Lag 0 (the day of exposure), a dose response relationship was observed: the odds ratios for Grades 2, 3, 4, and 5 above the referent (Grade 1) were 1.111 (95% confidence interval (CI): 0.995-1.239), 1.171 (95% CI: 1.006 -1.363), 1.357 (95% CI: 1.029-1.788), and 1.414 (95% CI: 0.983-2.036), respectively. Among the patients without asthma, the association was higher: the odds ratios for Grades 2, 3, 4 and 5 were 1.223 (95% CI: 0.999-1.497), 1309 (95% CI: 0.987-1.737), 1.738 (95% CI: 1.029-2.935) and 2.403 (95% CI: 1.158-4.985), respectively. These associations remained after adjusting for the concentration of spherical particles or particulate matter with an aerodynamic diameter of less than 2.5 mu m (PM2.5). Our findings demonstrate that kosa is an environmental factor which induces cough in a dose response relationship. (C) 2014 Elsevier Ltd. All rights reserved.